Literature DB >> 205429

Inhibition of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary by alrestatin.

W Lippmann.   

Abstract

Alrestatin at 25-1 X 10(-4) M inhibited the accumulation of cyclic AMP induced by prostaglandin E2, but not theophylline, in the rat anterior pituitary in vitro. Somatostatin, at lower concentrations, inhibited both; maximal inhibition of the prostaglandin effect was greater with alrestatin. As cyclic AMP is considered to be a mediator in induced-hormonal release, it appears from the present findings that alrestatin may be of potential use in altering hormonal release.

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Year:  1978        PMID： 205429     DOI： 10.1007/bf01935914

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

1.  Inhibition in the rat of gastric acid secretion and cyclic AMP analogs accumulation in vitro by somatostatin.

Authors:  W Lippmann
Journal:  Experientia       Date:  1977-01-15

2.  Synthesis of somatostatin.

Authors:  H U Immer; K Sestanj; V R Nelson; M Götz
Journal:  Helv Chim Acta       Date:  1974-04-27       Impact factor: 2.164

3.  Inhibition of adenosine 3',5'-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone.

Authors:  P Borgeat; F Labrie; J Drouin; A Bélanger; H Immer; K Sestanj; V Nelson; M Götz; A V Schally; D H Coy; E J Coy
Journal:  Biochem Biophys Res Commun       Date:  1974-02-27       Impact factor: 3.575

4.  Antagonism of prostaglandin-promoted pituitary cyclic AMP accumulation and growth hormone secretion in vitro by 7-oxa-13-prostynoic acid.

Authors:  A Ratner; M C Wilson; G T Peake
Journal:  Prostaglandins       Date:  1973-04

5.  Phosphodiesterase in tongue epithelium: activation by bitter taste stimuli.

Authors:  S Price
Journal:  Nature       Date:  1973-01-05       Impact factor: 49.962

6.  Studies on growth hormone secretion. II. Stimulation by prostaglandins in vitro.

Authors:  F Hertelendy
Journal:  Acta Endocrinol (Copenh)       Date:  1971-10

7.  Actinomycin-insensitive stimulation of protein synthesis in rat anterior pituitary in vitro by dibutyryl adenosine 3',5'-monophosphate.

Authors:  F Labrie; G Béraud; M Gauthier; A Lemay
Journal:  J Biol Chem       Date:  1971-03-25       Impact factor: 5.157

8.  Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone.

Authors:  S R Bloom; C H Mortimer; M O Thorner; G M Besser; R Hall; A Gomez-Pan; V M Roy; R C Russell; D H Coy; A J Kastin; A V Schally
Journal:  Lancet       Date:  1974-11-09       Impact factor: 79.321

9.  Inhibition of prostaglandin E2-induced cyclic amp accumulation in the rat anterior pituitary by 11-deoxyprostaglandin E analogs (9-ketoprostynoic acids).

Authors:  W Lippmann
Journal:  Prostaglandins       Date:  1975-09

10.  Stimulation of adenosine 3':5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by synthetic luteinizing hormone-releasing hormone.

Authors:  P Borgeat; G Chavancy; A Dupont; F Labrie; A Arimura; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205
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