| Literature DB >> 423181 |
G L Tong, D W Henry, E M Acton.
Abstract
Treatment of daunorubicin with methanolic ammonia affords 5-iminodaunorubicin, the first quinone-modified analogue of either daunorubicin or adriamycin. This product retains antileukemic activity in mice, is less cardiotoxic by electrocardiographic measurements in rats, and is nonmutagenic in Salmonella typhimurium (Ames test).Entities:
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Year: 1979 PMID： 423181 DOI： 10.1021/jm00187a009
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446