Literature DB >> 7438328

Effects of 5-iminodaunorubicin on nucleoli of rats.

J H Peters, M J Evans, R A Jensen, E M Acton.   

Abstract

We have confirmed that doxorubicin induces irreversible changes in the nucleolar ultrastructure of myocardial cells of rats. Similar changes were not caused by an equal dose of the synthetic analogue, 5-iminodaunomycin. These results combined with previous and current comparative tests with this analogue, doxorubicin, and daunomycin suggest that 5-iminodaunomycin may serve as a less cardiotoxic anthracycline derivative.

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Year:  1980        PMID： 7438328     DOI： 10.1007/bf00255271

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  10 in total

1.  Adriamycin-a review.

Authors:  S K Carter
Journal:  J Natl Cancer Inst       Date:  1975-12       Impact factor: 13.506

2.  Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents.

Authors:  J W Lown; H H Chen; J A Plambeck; E M Acton
Journal:  Biochem Pharmacol       Date:  1979-09-01       Impact factor: 5.858

3.  Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat.

Authors:  J A Merski; I Daskal; H Busch
Journal:  Cancer Res       Date:  1976-05       Impact factor: 12.701

4.  Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin.

Authors:  J Goodman; P Hochstein
Journal:  Biochem Biophys Res Commun       Date:  1977-07-25       Impact factor: 3.575

Review 5.  Adriamycin. A new anticancer drug with significant clinical activity.

Authors:  R H Blum; S K Carter
Journal:  Ann Intern Med       Date:  1974-02       Impact factor: 25.391

6.  NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

Authors:  N R Bachur; S L Gordon; M V Gee; H Kon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

Review 7.  Model systems for cardiotoxic effects of anthracyclines.

Authors:  G Zbinden; E Bachmann; C Holderegger
Journal:  Antibiot Chemother (1971)       Date:  1978

8.  5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline.

Authors:  G L Tong; D W Henry; E M Acton
Journal:  J Med Chem       Date:  1979-01       Impact factor: 7.446

9.  Acute ultrastructural effects of the antitumor antibiotic carminomycin on nucleoli of rat tissues.

Authors:  J A Merski; Y Daskal; S T Crooke; H Busch
Journal:  Cancer Res       Date:  1979-04       Impact factor: 12.701

10.  Myocardial injury induced by a single dose of adriamycin: an electron microscopic study.

Authors:  G Lambertenghi-Deliliers; P L Zanon; E F Pozzoli; O Bellini
Journal:  Tumori       Date:  1976 Sep-Oct
  10 in total
  1 in total

1.  Comparative cytotoxicities of various morpholinyl anthracyclines.

Authors:  D G Streeter; D L Taylor; E M Acton; J H Peters
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333
  1 in total

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