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Literature DB >> 6627601

Prevention of adriamycin toxicity.

A R Banks, T Jones, T H Koch, R D Friedman, N R Bachur.

Abstract

Mice treated with lethal doses of adriamycin (A1) (IP) are rescued with a single IP dose of 3,5,5-trimethyl-2-morpholinon-3-yl radical dimer (TM3). The in vivo rescue is assumed to be analogous to the in vitro reaction of TM3 with A1 that produces the non-toxic 7-deoxy-adriamycinone (7dAone). TM3 prevents death if given within 60 min following A1 administration. Control A1-treated mice died by 8 days (median survival time) whereas TM3 rescued A1-treated mice had a median survival time of greater than 60 days.

Entities: Chemical Disease Species

Mesh：

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Year: 1983 PMID： 6627601 DOI： 10.1007/bf00254252

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

14 in total

1. Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

Authors: N R Bachur; S L Gordon; M V Gee
Journal: Mol Pharmacol Date: 1977-09 Impact factor: 4.436

2. Adriamycin: amelioration of toxicity by alpha-tocopherol.

Authors: C E Myers; W McGuire; R Young
Journal: Cancer Treat Rep Date: 1976-07

3. A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

Authors: N R Bachur; S L Gordon; M V Gee
Journal: Cancer Res Date: 1978-06 Impact factor: 12.701

4. Adriamycin associated cardiotoxicity: research on prevention with coenzyme Q.

Authors: C Bertazzoli; M Ghione
Journal: Pharmacol Res Commun Date: 1977-03

5. Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping.

Authors: J W Lown; S K Sim; H H Chen
Journal: Can J Biochem Date: 1978-11

2. Experimental chemotherapy-induced skin necrosis in swine. Mechanistic studies of anthracycline antibiotic toxicity and protection with a radical dimer compound.

Authors: S D Averbuch; M Boldt; G Gaudiano; J B Stern; T H Koch; N R Bachur
Journal: J Clin Invest Date: 1988-01 Impact factor: 14.808

Review 3. A chemical perspective on the anthracycline antitumor antibiotics.

Authors: B R Abdella; J Fisher
Journal: Environ Health Perspect Date: 1985-12 Impact factor: 9.031

3 in total

Prevention of adriamycin toxicity.

1. Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

2. Adriamycin: amelioration of toxicity by alpha-tocopherol.

3. A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

4. Adriamycin associated cardiotoxicity: research on prevention with coenzyme Q.

5. Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping.

6. The effects of alpha-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice.

7. Antineoplastic activity and pharmacokinetics of adriamycin and daunomycin in tumor bearing mice.

8. Adriamycin analogues. 3. Synthesis of N-alkylated anthracyclines with enhanced efficacy and reduced cardiotoxicity.

9. Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.

10. Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria.

Review 1. Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

2. Experimental chemotherapy-induced skin necrosis in swine. Mechanistic studies of anthracycline antibiotic toxicity and protection with a radical dimer compound.

Review 3. A chemical perspective on the anthracycline antitumor antibiotics.