Literature DB >> 421804

The rate of action of cyclic ammonium and sulfonium analogues of acetylcholine.

G Lambrecht.   

Abstract

The rate of action of cyclic acetylcholine analogues in the 4-acetoxypiperidine and 4-acetoxythiacyclohexane series has been determined by using the isolated left guinea-pig atrium. The kinetic data obtained has been correlated with the experimental ED50-value on the muscarinic receptor.

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Year:  1979        PMID： 421804     DOI： 10.1007/bf01917886

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  ["Receptor-binding" of 14C-arecaidine derivatives by atrial tissue, as influenced by pH, atropine and membrane depolarization].

Authors:  H Lüllmann; A Ziegler
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1969

2.  An attempt to correlate kinetic data on the drug receptor interaction with the chemical structures of cholinomimetic agents.

Authors:  A Jung; H Lüllmann; A Ziegler
Journal:  Eur J Pharmacol       Date:  1971       Impact factor: 4.432

3.  Estimation of the cholinergic receptor occupation in guinea pig isolated atria by means of 14C-labelled arecaidine-derivatives.

Authors:  H Lüllmann; A Ziegler
Journal:  Eur J Pharmacol       Date:  1968-12       Impact factor: 4.432

4.  The rate of action of cholinergic drugs in guinea-pig isolated atria.

Authors:  D Bieger; E Krüger-Thiemer; H Lüllmann; A Ziegler
Journal:  Eur J Pharmacol       Date:  1970-02       Impact factor: 4.432

5.  Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation.

Authors:  D Hafner; E Heinen; E Noack
Journal:  Arzneimittelforschung       Date:  1977

6.  [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs. 5. The stereochemistry of cis- and trans-4-acetoxy-1-methylthioniacyclohexanes].

Authors:  G Lambrecht
Journal:  Arch Pharm (Weinheim)       Date:  1978-07       Impact factor: 3.751

7.  Rate of offset of action of slow-acting muscarinic antagonists is fast.

Authors:  T B Bolton
Journal:  Nature       Date:  1977-11-24       Impact factor: 49.962

8.  Structure-activity relationships of cyclic acetylcholine analogues of the piperidinol and thiacyclohexanol series.

Authors:  G Lambrecht
Journal:  Experientia       Date:  1976-03-15
  8 in total
  1 in total

1.  Dissociation constants of 4-acetoxy-piperidines and -thiacyclohexanes at the muscarinic receptor.

Authors:  G Lambrecht
Journal:  Experientia       Date:  1979-09-15
  1 in total

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