Literature DB >> 1253911

Structure-activity relationships of cyclic acetylcholine analogues of the piperidinol and thiacyclohexanol series.

G Lambrecht.   

Abstract

The hydrochlorides and methiodides of 1-methyl-3- and 4-acetoxypiperidine and their sulphonium analogues are cholinergic agonists. They are substrates for acetylcholinesterase. The sulphonium compounds have a 78(-524)-fold higher activity than its nitrogen analogues.

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Year:  1976        PMID： 1253911     DOI： 10.1007/BF01940841

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  1 in total

1.  [Structure- and conformation-activity relationships of cyclic acetylcholine analogs of the piperidine and quinuclidine series].

Authors:  G Lambrecht; E Mutschler
Journal:  Arzneimittelforschung       Date:  1974-11
  1 in total
  2 in total

1.  Dissociation constants of 4-acetoxy-piperidines and -thiacyclohexanes at the muscarinic receptor.

Authors:  G Lambrecht
Journal:  Experientia       Date:  1979-09-15

2.  The rate of action of cyclic ammonium and sulfonium analogues of acetylcholine.

Authors:  G Lambrecht
Journal:  Experientia       Date:  1979-01-15
  2 in total

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