Literature DB >> 579093

Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation.

D Hafner, E Heinen, E Noack.   

Abstract

The mathematical analysis of concentration-response relationships is performed by means of the mass law and the drug-receptor theory. It is demonstrated that the calculation of the median effective dose (ED50), which is decisive for the pharmacological characterisation of a certain drug, may only be effected by means of the logit transformation. In addition, it is shown that this transformation is most suitable to evaluate in a mathematically simple way the number of drug binding sites of the receptor molecule.

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Year:  1977        PMID： 579093

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


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