Literature DB >> 4065196

Further support for changes in chloroquine disposition and metabolism between a low and a high dose.

M Frisk-Holmberg, Y Bergqvist, E Termond.   

Abstract

The kinetics of chloroquine and its major metabolite desethylchloroquine were studied in patients with rheumatoid disease after single oral doses of chloroquine phosphate corresponding to 150 and 300 mg chloroquine base. The findings strengthen the previous finding that the disposition of chloroquine involves rate limiting steps.

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Year:  1985        PMID： 4065196     DOI： 10.1007/BF00607924

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  7 in total

1.  Steady state disposition of chloroquine in patients with rheumatoid disease.

Authors:  M Frisk-Holmberg; Y Bergqvist; B Domeij-Nyberg
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

2.  Determination of chloroquine and its desethyl metabolite in plasma, red blood cells and urine by liquid chromatography.

Authors:  G Alván; L Ekman; B Lindström
Journal:  J Chromatogr       Date:  1982-04-16

3.  The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.

Authors:  S Riegelman; P Collier
Journal:  J Pharmacokinet Biopharm       Date:  1980-10

4.  Chloroquine serum concentration and side effects: evidence for dose-dependent kinetics.

Authors:  M Frisk-Holmberg; Y Bergkvist; B Domeij-Nyberg; L Hellström; F Jansson
Journal:  Clin Pharmacol Ther       Date:  1979-03       Impact factor: 6.875

5.  Sensitive method for the determination of chloroquine and its metabolite desethyl-chloroquine in human plasma and urine by high-performance liquid chromatography.

Authors:  Y Bergqvist; M Frisk-Holmberg
Journal:  J Chromatogr       Date:  1980-11-14

6.  The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects.

Authors:  M Frisk-Holmberg; Y Bergqvist; E Termond; B Domeij-Nyberg
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

7.  On the question of dose-dependent chloroquine elimination of a single oral dose.

Authors:  L L Gustafsson; L Rombo; G Alván; A Björkman; M Lind; O Walker
Journal:  Clin Pharmacol Ther       Date:  1983-09       Impact factor: 6.875
  7 in total
  5 in total

1.  Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times.

Authors:  S E Tett; D J Cutler
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

2.  Variation in chloroquine pharmacokinetics due to assay sensitivity and duration of sampling.

Authors:  M Frisk-Holmberg
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

Review 3.  Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements.

Authors:  J Ducharme; R Farinotti
Journal:  Clin Pharmacokinet       Date:  1996-10       Impact factor: 6.447

4.  A dose-ranging study of the pharmacokinetics of hydroxy-chloroquine following intravenous administration to healthy volunteers.

Authors:  S E Tett; D J Cutler; R O Day; K F Brown
Journal:  Br J Clin Pharmacol       Date:  1988-09       Impact factor: 4.335

5.  Comparative bioavailability of rectal and oral formulations of chloroquine.

Authors:  M M Tjoeng; P H Hogeman; H Kapelle; M L De Ridder; H Verhaar
Journal:  Pharm Weekbl Sci       Date:  1991-08-23
  5 in total

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