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Literature DB >> 1945743

Comparative bioavailability of rectal and oral formulations of chloroquine.

M M Tjoeng¹, P H Hogeman, H Kapelle, M L De Ridder, H Verhaar.

Abstract

The relative bioavailability of chloroquinone in Witepsol H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.

Entities: Chemical

Mesh：

Substances：
Chloroquine

Year: 1991 PMID： 1945743 DOI： 10.1007/bf01957742

Source DB: PubMed Journal: Pharm Weekbl Sci ISSN： 0167-6555

11 in total

1. Determination of chloroquine and its desethyl metabolite in plasma, red blood cells and urine by liquid chromatography.

Authors: G Alván; L Ekman; B Lindström
Journal: J Chromatogr Date: 1982-04-16

2. Further support for changes in chloroquine disposition and metabolism between a low and a high dose.

Authors: M Frisk-Holmberg; Y Bergqvist; E Termond
Journal: Eur J Clin Pharmacol Date: 1985 Impact factor: 2.953

Review 3. Prevention of malaria.

Authors: J S Keystone
Journal: Drugs Date: 1990-03 Impact factor: 9.546

Review 4. Clinical pharmacokinetics of antimalarial drugs.

Authors: N J White
Journal: Clin Pharmacokinet Date: 1985 May-Jun Impact factor: 6.447

Review 5. Rectal drug administration: clinical pharmacokinetic considerations.

Authors: A G de Boer; F Moolenaar; L G de Leede; D D Breimer
Journal: Clin Pharmacokinet Date: 1982 Jul-Aug Impact factor: 6.447

6. On the question of dose-dependent chloroquine elimination of a single oral dose.

Authors: L L Gustafsson; L Rombo; G Alván; A Björkman; M Lind; O Walker
Journal: Clin Pharmacol Ther Date: 1983-09 Impact factor: 6.875

7. Disposition of chloroquine in man after single intravenous and oral doses.

Authors: L L Gustafsson; O Walker; G Alván; B Beermann; F Estevez; L Gleisner; B Lindström; F Sjöqvist
Journal: Br J Clin Pharmacol Date: 1983-04 Impact factor: 4.335

8. Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma.

Authors: Y Bergqvist; B Domeij-Nyberg
Journal: J Chromatogr Date: 1983-01-14

Comparative bioavailability of rectal and oral formulations of chloroquine.

1. Determination of chloroquine and its desethyl metabolite in plasma, red blood cells and urine by liquid chromatography.

2. Further support for changes in chloroquine disposition and metabolism between a low and a high dose.

Review 3. Prevention of malaria.

Review 4. Clinical pharmacokinetics of antimalarial drugs.

Review 5. Rectal drug administration: clinical pharmacokinetic considerations.

6. On the question of dose-dependent chloroquine elimination of a single oral dose.

7. Disposition of chloroquine in man after single intravenous and oral doses.

8. Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma.

9. Chloroquine absorption in children from polyethylene glycol base suppositories.

10. Chloroquine-resistant falciparum malaria imported into the Netherlands.

1. On the question of interindividual variations in chloroquine concentrations.

Review 2. Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.