Literature DB >> 310749

Chloroquine serum concentration and side effects: evidence for dose-dependent kinetics.

M Frisk-Holmberg, Y Bergkvist, B Domeij-Nyberg, L Hellström, F Jansson.   

Abstract

Serum concentrations of chloroquine were determined fluorometrically in 100 rheumatoid patients who had been treated with 0.25 gm daily for at least 2 mo. The total dose varied between 3.7 and 400 gm. No patient received more than 75 gm annually. In 15% of the patients side effects were noted. There was a relationship between serum concentrations and side effects but not with the total dose administered. Chloroquine displayed dose-dependent kinetics, which may indicate that close monitoring of serum concentrations is an aid to the safe and rational use of the drug.

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Year:  1979        PMID： 310749     DOI： 10.1002/cpt1979253345

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  38 in total

1.  Massive chloroquine overdose--a survivor.

Authors:  G Stiff; D Robinson; H L Cugnoni; R Touquet; A M Dalton
Journal:  Postgrad Med J       Date:  1991-07       Impact factor: 2.401

2.  Pharmacokinetics of chloroquine: saliva and plasma levels relationship.

Authors:  E I Ette; E E Essien; E E Brown-Awala
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Oct-Dec       Impact factor: 2.441

3.  Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times.

Authors:  S E Tett; D J Cutler
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

4.  Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain.

Authors:  P Donatelli; G Marchi; L Giuliani; L L Gustafsson; G M Pacifici
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

Review 5.  Clinical pharmacokinetics of antimalarial drugs.

Authors:  N J White
Journal:  Clin Pharmacokinet       Date:  1985 May-Jun       Impact factor: 6.447

6.  Population pharmacokinetics of chloroquine and sulfadoxine and treatment response in children with malaria: suggestions for an improved dose regimen.

Authors:  Celestino Obua; Urban Hellgren; Muhammed Ntale; Lars L Gustafsson; Jasper W Ogwal-Okeng; Toufigh Gordi; Markus Jerling
Journal:  Br J Clin Pharmacol       Date:  2008-02-20       Impact factor: 4.335

7.  The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects.

Authors:  M Frisk-Holmberg; Y Bergqvist; E Termond; B Domeij-Nyberg
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

8.  Cardiovascular toxicity and distribution kinetics of intravenous chloroquine.

Authors:  S Looareesuwan; N J White; P Chanthavanich; G Edwards; D D Nicholl; C Bunch; D A Warrell
Journal:  Br J Clin Pharmacol       Date:  1986-07       Impact factor: 4.335

Review 9.  Clinical pharmacokinetics of drugs used in juvenile arthritis.

Authors:  K J Skeith; F Jamali
Journal:  Clin Pharmacokinet       Date:  1991-08       Impact factor: 6.447

10.  A dose-ranging study of the pharmacokinetics of hydroxy-chloroquine following intravenous administration to healthy volunteers.

Authors:  S E Tett; D J Cutler; R O Day; K F Brown
Journal:  Br J Clin Pharmacol       Date:  1988-09       Impact factor: 4.335
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