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Literature DB >> 3556380

Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times.

Abstract

We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are collected over a short period or if they are assayed with a method of low sensitivity.

Entities: Chemical

Mesh：

Substances：
Chloroquine

Year: 1987 PMID： 3556380 DOI： 10.1007/BF00541305

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

7 in total

1. Kinetics of chloroquine & contraceptive steroids in oral contraceptive users during concurrent chloroquine prophylaxis.

Authors: K C Gupta; J V Joshi; N K Desai; G M Sankolli; V N Chowdhary; U M Joshi; S Chitalange; R S Satoskar
Journal: Indian J Med Res Date: 1984-12 Impact factor: 2.375

2. Further support for changes in chloroquine disposition and metabolism between a low and a high dose.

Authors: M Frisk-Holmberg; Y Bergqvist; E Termond
Journal: Eur J Clin Pharmacol Date: 1985 Impact factor: 2.953

3. Chloroquine serum concentration and side effects: evidence for dose-dependent kinetics.

Authors: M Frisk-Holmberg; Y Bergkvist; B Domeij-Nyberg; L Hellström; F Jansson
Journal: Clin Pharmacol Ther Date: 1979-03 Impact factor: 6.875

4. The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects.

Authors: M Frisk-Holmberg; Y Bergqvist; E Termond; B Domeij-Nyberg
Journal: Eur J Clin Pharmacol Date: 1984 Impact factor: 2.953

5. On the question of dose-dependent chloroquine elimination of a single oral dose.

Authors: L L Gustafsson; L Rombo; G Alván; A Björkman; M Lind; O Walker
Journal: Clin Pharmacol Ther Date: 1983-09 Impact factor: 6.875

6. Chloroquine kinetics in the undernourished.

Authors: A Tulpule; K Krishnaswamy
Journal: Eur J Clin Pharmacol Date: 1983 Impact factor: 2.953

7. Disposition of chloroquine in man after single intravenous and oral doses.

Authors: L L Gustafsson; O Walker; G Alván; B Beermann; F Estevez; L Gleisner; B Lindström; F Sjöqvist
Journal: Br J Clin Pharmacol Date: 1983-04 Impact factor: 4.335

7 in total

15 in total

1. Evaluation of pharmacokinetic studies: is it useful to take into account concentrations below the limit of quantification?

Authors: H Humbert; M D Cabiac; J Barradas; C Gerbeau
Journal: Pharm Res Date: 1996-06 Impact factor: 4.200

2. Variation in chloroquine pharmacokinetics due to assay sensitivity and duration of sampling.

Authors: M Frisk-Holmberg
Journal: Eur J Clin Pharmacol Date: 1987 Impact factor: 2.953

3. Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.

Authors: Brioni R Moore; Madhu Page-Sharp; Jillian R Stoney; Kenneth F Ilett; Jeffrey D Jago; Kevin T Batty
Journal: Antimicrob Agents Chemother Date: 2011-06-06 Impact factor: 5.191

Review 4. Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements.

Authors: J Ducharme; R Farinotti
Journal: Clin Pharmacokinet Date: 1996-10 Impact factor: 6.447

5. Interpretation of chloroquine pharmacokinetic data.

Authors: A McLachlan; S Tett; R Day; D Cutler
Journal: Eur J Clin Pharmacol Date: 1993 Impact factor: 2.953

6. Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy.

Authors: Harin A Karunajeewa; Sam Salman; Ivo Mueller; Francisca Baiwog; Servina Gomorrai; Irwin Law; Madhu Page-Sharp; Stephen Rogerson; Peter Siba; Kenneth F Ilett; Timothy M E Davis
Journal: Antimicrob Agents Chemother Date: 2010-01-19 Impact factor: 5.191

7. Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax.

Authors: Hyeong-Seok Lim; Jeong-Soo Im; Joo-Youn Cho; Kyun-Seop Bae; Terry A Klein; Joon-Sup Yeom; Tae-Seon Kim; Jae-Seon Choi; In-Jin Jang; Jae-Won Park
Journal: Antimicrob Agents Chemother Date: 2009-02-02 Impact factor: 5.191

8. Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women.

9. A dose-ranging study of the pharmacokinetics of hydroxy-chloroquine following intravenous administration to healthy volunteers.

Authors: S E Tett; D J Cutler; R O Day; K F Brown
Journal: Br J Clin Pharmacol Date: 1988-09 Impact factor: 4.335

10. Bioavailability of hydroxychloroquine tablets in healthy volunteers.

Authors: S E Tett; D J Cutler; R O Day; K F Brown
Journal: Br J Clin Pharmacol Date: 1989-06 Impact factor: 4.335