Literature DB >> 4050872

Excess thymidine induces folate sensitive fragile sites.

G R Sutherland, E Baker, A Fratini.   

Abstract

Folate sensitive fragile sites on human chromosomes have been found to be inducible in cultured lymphocytes by high levels of thymidine but not by high levels of BrdU. The biochemical interpretation of events leading to fragile site expression has been revised since it is now clear that low levels of either thymidylate or deoxycytidine triphosphate will result in this phenomenon. A model for the DNA at a fragile site, composed of alternating repeating polypurine/polypyrimidine sequences is proposed.

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Year:  1985        PMID： 4050872     DOI： 10.1002/ajmg.1320220234

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  21 in total

Review 1.  Advanced technologies for the molecular diagnosis of fragile X syndrome.

Authors:  Flora Tassone
Journal:  Expert Rev Mol Diagn       Date:  2015-10-21       Impact factor: 5.225

2.  Uridine enhances expression of the fragile X chromosome in human lymphocytes.

Authors:  M Kähkönen; R Haataja; J Leisti
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

3.  A single lymphocyte culture for fragile X induction and prometaphase chromosome analysis.

Authors:  M J Griffiths; M C Strachan
Journal:  J Med Genet       Date:  1991-12       Impact factor: 6.318

4.  Improved fragile site detection with trimethoprim.

Authors:  D A McLean; M J Faed
Journal:  Hum Genet       Date:  1990-07       Impact factor: 4.132

5.  Cell type-dependent difference in the distribution and frequency of excess thymidine-induced common fragile sites: T lymphocytes and skin fibroblasts.

Authors:  A Kuwano; I Murano; T Kajii
Journal:  Hum Genet       Date:  1990-05       Impact factor: 4.132

6.  Cytological evidence of defective template in the fragile X chromosome.

Authors:  B Kerem; R Goitein; T Schaap
Journal:  Chromosoma       Date:  1988       Impact factor: 4.316

7.  Studies on three rare fragile sites. 2q13, 12q13, and 17p12 segregating in one family.

Authors:  D R Romain; L M Columbano-Green; R H Smythe; R G Parfitt; O B Gebbie; C J Chapman
Journal:  Hum Genet       Date:  1986-06       Impact factor: 4.132

8.  Induction of fragile sites in fibroblasts.

Authors:  G R Sutherland; E Baker
Journal:  Am J Hum Genet       Date:  1986-04       Impact factor: 11.025

9.  Induction of the fragile X on BrdU-substituted chromosomes with direct visualization of sister chromatid exchanges on banded chromosomes.

Authors:  N Tommerup
Journal:  Hum Genet       Date:  1989-03       Impact factor: 4.132

10.  Difficult diagnosis of the fragile X syndrome made possible by direct detection of DNA mutations.

Authors:  J Tarleton; S Wong; D Heitz; C Schwartz
Journal:  J Med Genet       Date:  1992-10       Impact factor: 6.318
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