Literature DB >> 2939714

Induction of fragile sites in fibroblasts.

G R Sutherland, E Baker.   

Abstract

A simple, reliable method for the induction of folate-sensitive fragile sites, including the fragile X, in fibroblasts is described. The method involves only the addition of 600 mg/l thymidine to cultures 24 hrs before they are harvested.

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Year:  1986        PMID： 2939714      PMCID： PMC1684789     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  8 in total

1.  Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

2.  First trimester prenatal diagnosis of a male fetus with fragile X.

Authors:  N Tommerup; F Søndergaard; T Tønnesen; M Kristensen; B Arveiler; A Schinzel
Journal:  Lancet       Date:  1985-04-13       Impact factor: 79.321

3.  Marker X chromosome induction in fibroblasts by FUdR.

Authors:  N Tommerup; K B Nielssen; M Mikkelsen
Journal:  Am J Med Genet       Date:  1981

4.  A simple method to demonstrate the fragile X chromosome in fibroblasts.

Authors:  C Fonatsch
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

5.  Expression in lymphocyte and fibroblast culture of the fragile X chromosome: a new technical approach.

Authors:  M G Mattei; J F Mattei; I Vidal; F Giraud
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

6.  Excess thymidine induces folate sensitive fragile sites.

Authors:  G R Sutherland; E Baker; A Fratini
Journal:  Am J Med Genet       Date:  1985-10

7.  DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

Authors:  T W Glover; C Berger; J Coyle; B Echo
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

8.  FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

Authors:  T W Glover
Journal:  Am J Hum Genet       Date:  1981-03       Impact factor: 11.025
  8 in total
  2 in total

1.  Cell type-dependent difference in the distribution and frequency of excess thymidine-induced common fragile sites: T lymphocytes and skin fibroblasts.

Authors:  A Kuwano; I Murano; T Kajii
Journal:  Hum Genet       Date:  1990-05       Impact factor: 4.132

2.  Fibroblast-specific common fragile sites induced by aphidicolin.

Authors:  I Murano; A Kuwano; T Kajii
Journal:  Hum Genet       Date:  1989-08       Impact factor: 4.132
  2 in total

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