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Literature DB >> 4042462

Enhancement of in vitro chemotherapeutic activity by dimethylsulfoxide.

Abstract

The effects of the differentiation-inducing polar solvent dimethylsulfoxide (DMSO) on the in vitro response of murine hepatocarcinoma cells to cisplatinum, BCNU, and melphalan were investigated using the sister chromatid exchange (SCE) and cell survival assays. Growth of cells in medium containing 2 per cent DMSO enhanced drug-induced SCEs and cell kill. In order for the enhancement to occur, cells had to be exposed to DMSO for at least 48 h prior to drug treatment. The presence of DMSO during drug treatment did not affect cell response to the three chemotherapeutic agents. The enhancement of chemosensitivity was eliminated within 24 h of DMSO removal. These data suggest that the differentiation-inducing polar solvents may provide antineoplastic benefits when administered in combination with standard chemotherapeutic agents.

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Year: 1985 PMID： 4042462 DOI： 10.1007/bf01758962

Source DB: PubMed Journal: Clin Exp Metastasis ISSN： 0262-0898 Impact factor: 5.150

26 in total

1. Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation.

Authors: G H Lyman; H D Preisler; D Papahadjopoulos
Journal: Nature Date: 1976-07-29 Impact factor: 49.962

2. Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide.

Authors: C Friend; W Scher; J G Holland; T Sato
Journal: Proc Natl Acad Sci U S A Date: 1971-02 Impact factor: 11.205

3. Carrier-dependent and carrier-independent transport of anti-cancer alkylating agents.

Authors: J E Byfield; P M Calabro-Jones
Journal: Nature Date: 1981-11-19 Impact factor: 49.962

4. Alteration of the survival response of two human colon carcinoma subpopulations to x-irradiation by N,N-dimethylformamide.

Authors: J T Leith; L A Gaskins; D L Dexter; P Calabresi; A S Glicksman
Journal: Cancer Res Date: 1982-01 Impact factor: 12.701

5. Prediction of the relative in vitro sensitivity of 9L rat brain tumor cells to nitrosoureas by the sister chromatid exchange assay.

Authors: P J Tofilon; M A Gerosa; M L Rosenblum; W J Bodell; D F Deen
Journal: Life Sci Date: 1984-10-08 Impact factor: 5.037

6. Polyamine depletion influences drug-induced chromosomal damage.

Authors: P J Tofilon; S M Oredsson; D F Deen; L J Marton
Journal: Science Date: 1982-09-10 Impact factor: 47.728

7. Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

Authors: S J Collins; F W Ruscetti; R E Gallagher; R C Gallo
Journal: Proc Natl Acad Sci U S A Date: 1978-05 Impact factor: 11.205

4. Differentiation-inducing therapeutic effect of Notch inhibition in reversing malignant transformation of liver normal stem cells via MET.

Authors: Hao Luo; Wei-Hui Liu; Hong-Yin Liang; Hong-Tao Yan; Ning Lin; Dong-Yu Li; Tao Wang; Li-Jun Tang
Journal: Oncotarget Date: 2018-02-05

4 in total

Enhancement of in vitro chemotherapeutic activity by dimethylsulfoxide.

1. Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation.

2. Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide.

3. Carrier-dependent and carrier-independent transport of anti-cancer alkylating agents.

4. Alteration of the survival response of two human colon carcinoma subpopulations to x-irradiation by N,N-dimethylformamide.

5. Prediction of the relative in vitro sensitivity of 9L rat brain tumor cells to nitrosoureas by the sister chromatid exchange assay.

6. Polyamine depletion influences drug-induced chromosomal damage.

7. Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

8. Prediction of in vivo tumor response to chemotherapeutic agents by the in vitro sister chromatid exchange assay.

9. Protection against cis-dichlorodiammine Pt (II) cytotoxicity in vitro by cysteamine.

10. N-methylformamide: antitumour activity and metabolism in mice.

1. Dimethylsulfoxide enhances the absorption of chemotherapeutic drug instilled into the bladder.

2. N-methylformamide-mediated enhancement of in vitro tumor cell chemosensitivity.

3. Intravesical chemotherapy: combination with dimethyl sulfoxide does not enhance cytotoxicity in vitro.

4. Differentiation-inducing therapeutic effect of Notch inhibition in reversing malignant transformation of liver normal stem cells via MET.