Literature DB >> 6810463

Polyamine depletion influences drug-induced chromosomal damage.

P J Tofilon, S M Oredsson, D F Deen, L J Marton.   

Abstract

Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.

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Year:  1982        PMID： 6810463     DOI： 10.1126/science.6810463

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Specific requirement of putrescine for the mitogenic action of juvenile hormone on adult insect neuroblasts.

Authors:  M Cayre; C Strambi; P Charpin; R Augier; A Strambi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

2.  Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.

Authors:  A J Bitonti; J A Dumont; T L Bush; M L Edwards; D M Stemerick; P P McCann; A Sjoerdsma
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

Review 3.  The chemotherapeutic potential of polyamine antimetabolites.

Authors:  A N Kingsnorth
Journal:  Ann R Coll Surg Engl       Date:  1986-03       Impact factor: 1.891

Review 4.  DNA topoisomerase II as a target of antineoplastic drug therapy.

Authors:  L A Zwelling
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

5.  Enhancement of in vitro chemotherapeutic activity by dimethylsulfoxide.

Authors:  P J Tofilon; C M Vines; L Milas
Journal:  Clin Exp Metastasis       Date:  1985 Apr-Jun       Impact factor: 5.150

6.  Polyamines in clinical disorders.

Authors:  D F Tierney; L J Marton; A D Hacker; N Lowe
Journal:  West J Med       Date:  1985-01

7.  N-methylformamide-mediated enhancement of in vitro tumor cell chemosensitivity.

Authors:  P J Tofilon; C M Vines; L Milas
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

8.  Effects of alpha-difluoromethylornithine on initiation and promotion of urinary bladder carcinogenesis in a heterotopically transplanted rat urinary bladder.

Authors:  K Rinsho; K Uchida; S Samma; R Oyasu
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

9.  Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.

Authors:  A B Clarkson; C J Bacchi; G H Mellow; H C Nathan; P P McCann; A Sjoerdsma
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

10.  Response to BCNU of spheroids grown from mixtures of drug-sensitive and drug-resistant cells.

Authors:  P J Tofilon; C M Arundel; D F Deen
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333
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