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Literature DB >> 3176208

Intravesical chemotherapy: combination with dimethyl sulfoxide does not enhance cytotoxicity in vitro.

L Walker¹, M C Walker, C N Parris, J R Masters.

Abstract

There is evidence that dimethyl sulfoxide (DMSO) can increase the anticancer activity of chemotherapeutic drugs. As DMSO is instilled into the bladder for interstitial cystitis, it could be readily adopted in clinical practice if it was found to enhance the effectiveness of the drugs used for intravesical chemotherapy. The purpose of this study was to investigate, using a human bladder cancer cell line, the hypothesis that DMSO enhances the activity of these agents. However, the addition of 4% DMSO to the four drugs most frequently used for intravesical chemotherapy (adriamycin, epodyl, mitomycin-c, thiotepa) did not increase tumour cell kill in vitro.

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Year: 1988 PMID： 3176208 DOI： 10.1007/bf00263647

Source DB: PubMed Journal: Urol Res ISSN： 0300-5623

20 in total

3. Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman S-91 (M3) murine melanoma cell line.

Authors: Joan McIntyre Caron; Marissa Bannon; Lindsay Rosshirt; Jessica Luis; Luke Monteagudo; John M Caron; Gerson Marc Sternstein
Journal: PLoS One Date: 2010-08-04 Impact factor: 3.240

3 in total

Intravesical chemotherapy: combination with dimethyl sulfoxide does not enhance cytotoxicity in vitro.

1. Intravesical chemotherapy. Studies on the relationship between pH and cytotoxicity.

2. Intravesical chemotherapy: combination with Tween 80 increases cytotoxicity in vitro.

3. The treatment of patients with interstitial cystitis, with special reference to intravesical DMSO.

4. Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.

5. The plight of the patient with carcinoma in situ of the bladder.

Review 6. Intravesical chemotherapy of superficial bladder cancer.

7. Chromosome pattern, growth in agar and tumorigenicity in nude mice of four human bladder carcinoma cell lines.

Review 8. The biology and treatment of superficial bladder cancer.

9. Enhancement of in vitro chemotherapeutic activity by dimethylsulfoxide.

10. Mechanisms of the synergistic effect of oral dimethyl sulfoxide on antineoplastic therapy.

1. Dimethylsulfoxide enhances the absorption of chemotherapeutic drug instilled into the bladder.

Review 2. Current recommendations for the management of bladder cancer. Drug therapy.

3. Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman S-91 (M3) murine melanoma cell line.