Literature DB >> 4038983

Genetic regulation of immunoglobulin and specific antibody levels in twins reared apart.

P F Kohler, V J Rivera, E D Eckert, T J Bouchard, L L Heston.   

Abstract

We studied the effect of the same genetic but different environmental factors on total immunoglobulin and specific antibody levels in twins reared apart. Sera were analyzed from 26 monozygotic (MZ) and 10 dizygotic (DZ) twin pairs, who were separated on average 2 mo after birth and reared apart. Total IgM, IgG, and IgA were measured by single radial diffusion. Specific antibodies of each isotype to tetanus toxoid, and to polyvalent and type 14 pneumococcal capsular polysaccharides were measured by a solid-phase antigen-enzyme-labeled anti-Ig immunoassay. One-way analysis of variance showed intrapair total Ig and antibody levels to be more highly correlated in MZ compared with DZ twins. Our results indicate that genetic factors are more important than environment in regulating these humoral immune responses.

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Year:  1985        PMID： 4038983      PMCID： PMC423619          DOI： 10.1172/JCI111787

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  13 in total

1.  The genetic control of response to antigenic stimuli.

Authors:  J H SANG; W R SOBEY
Journal:  J Immunol       Date:  1954-01       Impact factor: 5.422

2.  The serum Ig level in human twins.

Authors:  A O Carbonara; R Ceppellini; W Yount; S Landucci
Journal:  Acta Genet Med Gemellol (Roma)       Date:  1970 Jan-Apr

3.  Plasma immunoglobulin concentrations in twins.

Authors:  D S Rowe; J A Boyle; W W Buchanan
Journal:  Clin Exp Immunol       Date:  1968-03       Impact factor: 4.330

4.  Serum immunoglobulin levels in twins.

Authors:  M W Kalff; W Hijmans
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5.  The influence of heredity and environment on human immunoglobulin levels.

Authors:  M Allansmith; B McClellan; M Butterworth
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6.  The diagnosis of zygosity in twins.

Authors:  D T Lykken
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7.  Genetic influence on serum igd levels.

Authors:  S K Lee; J D Metrakos; K R Tanaka; D C Heiner
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8.  ELISA methodology for polysaccharide antigens: protein coupling of polysaccharides for adsorption to plastic tubes.

Authors:  B M Gray
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9.  Ragweed hay fever: genetic control and linkage to HL-A haplotypes.

Authors:  B B Levine; R H Stember; M Fotino
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