Literature DB >> 4637806

Ragweed hay fever: genetic control and linkage to HL-A haplotypes.

B B Levine, R H Stember, M Fotino.   

Abstract

Clinical ragweed pollenosis (hay fever) and IgE antibody production specific for antigen E (the major purified protein antigen from ragweed pollen extract) correlated closely with HL-A haplotypes in successive generations of seven families. HL-A associated IgE antibody responsiveness was antigen specific and extended also to IgE antibody production. These data indicate an immune response (Ir) gene specific for antigen E necessary but not sufficient for the development of hay fever. This appears to be the first documentation of an Ir gene in man.

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Year:  1972        PMID： 4637806     DOI： 10.1126/science.178.4066.1201

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  56 in total

Review 1.  [Leukocyte antigens and their clinical significance].

Authors:  W R Mayr
Journal:  Blut       Date:  1975-12

2.  Hepatitis B antigen (HBAg) infection in a hemodialysis unit. I. HL-A8 and immune response to HBAg.

Authors:  D P Sengar; W A McLeish; M Sutherland; R A Couture; A Rashid
Journal:  Can Med Assoc J       Date:  1975-04-19       Impact factor: 8.262

3.  Lymphocyte response to IgG in patients with ankylosing spondylitis and their families.

Authors:  R H Weisbart; R I Morris; P I Terasaki; R Bluestone; L S Goldberg
Journal:  Clin Exp Immunol       Date:  1976-12       Impact factor: 4.330

4.  Segregation analysis of IgE responses to Cryptomeria japonica pollen antigen in vivo.

Authors:  K Honda; S Matsushita; N Yasuda; T Juji; T Sasazuki; T Uemura
Journal:  Eur Arch Otorhinolaryngol       Date:  1994       Impact factor: 2.503

Review 5.  Drug-induced lung disease.

Authors:  P Cole
Journal:  Drugs       Date:  1977-06       Impact factor: 9.546

6.  HL-A antigens in North American black families.

Authors:  F E Ward; A A Biegel
Journal:  Am J Hum Genet       Date:  1976-01       Impact factor: 11.025

7.  Conversion of human erythrocyte-adenosine deaminase activity to different tissue-specific isozymes. Evidence for a common catalytic unit.

Authors:  R Hirschhorn
Journal:  J Clin Invest       Date:  1975-03       Impact factor: 14.808

8.  Atopy as a minimal immunodeficiency?

Authors:  G R Burgio; L Nespoli; A G Ugazio
Journal:  Eur J Pediatr       Date:  1978-12-01       Impact factor: 3.183

9.  HLA-B13 and chronic calcific pancreatitis.

Authors:  L Gullo; P L Tabacchi; G R Corazza; F Calanca; O Campione; G Labò
Journal:  Dig Dis Sci       Date:  1982-03       Impact factor: 3.199

10.  Role of antigen structure in the regulation of IgE isotype expression.

Authors:  T Francus; G W Siskind; C G Becker
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205
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