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Literature DB >> 4038969

Analysis of the fragile-X chromosome: localization and detection of the fragile site in high resolution preparations.

Abstract

Fragile X chromosome preparations were analyzed at levels of up to 850 bands per haploid set. We were able to consistently sublocalize the Xqter fragile site to band Xq27.3 using high-resolution methods. Chromosome length versus the frequency of fragile X expression was also compared. The fragile site appeared at a higher percentage in more condensed chromosome preparations. The importance of this finding is that high-resolution chromosome preparations do not optimize fragile-X detection.

Entities: Disease

Mesh：

Year: 1985 PMID： 4038969 DOI： 10.1007/bf00293026

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

17 in total

1. Rapid processing of primary embryonic tissues for chromosome banding pattern analysis.

Authors: H P Klinger
Journal: Cytogenetics Date: 1972

2. Fragile X chromosome and chromosome condensation.

Authors: P B Jacky; F J Dill
Journal: Ann Genet Date: 1983

3. In vitro reversal of fragile-X expression by exogenous thymidine.

Authors: G B Gardiner; S L Wenger; M W Steele
Journal: Clin Genet Date: 1984-02 Impact factor: 4.438

4. The fragile X(q27) form of X-linked mental retardation: FUdR as an inducing agent for fra(X)(q27) expression in lymphocytes, fibroblasts, and amniocytes.

Authors: R Brookwell; A Daniel; G Turner; J Fishburn
Journal: Am J Med Genet Date: 1982-10

5. The fragile X: a scanning electron microscope study.

Authors: C J Harrison; E M Jack; T D Allen; R Harris
Journal: J Med Genet Date: 1983-08 Impact factor: 6.318

6. High resolution banding and the locus of the Xq fragile site.

Authors: R Brookwell; G Turner
Journal: Hum Genet Date: 1983 Impact factor: 4.132

7. The strength of association between fragile (X) chromosome presence and mental retardation.

Authors: W Silverman; R Lubin; E C Jenkins; W T Brown
Journal: Clin Genet Date: 1983-06 Impact factor: 4.438

8. Manifestation of the fragile site Xq27 in fibroblasts. III. A method to demonstrate R-type replication patterns and the fragile site.

Authors: G Barbi; P Steinbach; A Wiedenmann; W Vogel
Journal: Hum Genet Date: 1983 Impact factor: 4.132

9. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

Authors:
Journal: Cytogenet Cell Genet Date: 1981

10. FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

Authors: T W Glover
Journal: Am J Hum Genet Date: 1981-03 Impact factor: 11.025

17 in total

1. Genetic mapping of two new DNA markers in Xq26-q28 relative to the fragile-X syndrome locus.

Authors: R Sood; L M Mulligan; R Poon; B N White; J J Holden
Journal: Am J Hum Genet Date: 1990-09 Impact factor: 11.025

Review 2. The fragile X: progress toward solving the puzzle.

Authors: W T Brown
Journal: Am J Hum Genet Date: 1990-08 Impact factor: 11.025

3. Dissociation between mental retardation and fragile site expression in a family with fragile X-linked mental retardation.

Authors: M A Voelckel; M G Mattei; C N'Guyen; N Philip; F Birg; J F Mattei
Journal: Hum Genet Date: 1988-12 Impact factor: 4.132

4. In situ hybridization studies using a molecular probe that maps to Xq27-Zq28.

Authors: A M Duncan; C Morgan
Journal: Hum Genet Date: 1990-04 Impact factor: 4.132

5. Further evidence localising the gene for Hunter's syndrome to the distal region of the X chromosome long arm.

Authors: S H Roberts; M Upadhyaya; M Sarfarazi; P S Harper
Journal: J Med Genet Date: 1989-05 Impact factor: 6.318

6. Fragile X syndrome: clinical, cytogenetic, biochemical and molecular features.

Authors: J C Mixon; V G Dev
Journal: Indian J Pediatr Date: 1986 Jul-Aug Impact factor: 1.967

7. Linkage analysis using multiple Xq DNA polymorphisms in normal families, families with the fragile X syndrome, and other families with X linked conditions.

Authors: J M Connor; L A Pirrit; J R Yates; J A Crossley; S J Imrie; J M Colgan
Journal: J Med Genet Date: 1987-01 Impact factor: 6.318