| Literature DB >> 6231141 |
G B Gardiner, S L Wenger, M W Steele.
Abstract
A virtually thymidine free medium was used to test the effects of exogenous thymidine on lymphocyte expression of the fragile-X. De novo pathway thymidylic acid synthesis in the cells was blocked by FUdR. Our results suggest that in vitro exogenous thymidine is directly responsible for suppressing expression of the fragile-X. More importantly, delayed addition of exogenous thymidine can negate fragile-X expression after it has first been induced by FUdR.Entities:
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Year: 1984 PMID： 6231141 DOI： 10.1111/j.1399-0004.1984.tb00475.x
Source DB: PubMed Journal: Clin Genet ISSN： 0009-9163 Impact factor: 4.438