| Literature DB >> 3968690 |
D M Bailey, P E Hansen, A G Hlavac, E R Baizman, J Pearl, A F DeFelice, M E Feigenson.
Abstract
A small series of compounds is described in which a narrow SAR has identified N,N-dimethyl-3,4-diphenyl-1H-pyrazole-1-propanamine, 3, as a potential antidepressant with reduced side effects. The isomeric N,N-dimethyl-4,5-diphenyl-1H-pyrazole-1-propanamine was completely inactive in the primary antidepressant screens. Compounds were synthesized by Michael addition of acrylonitrile to diphenylpyrazole followed by reductive alkylation of the resultant diphenylpyrazolepropionitriles. Compound 3 was equipotent with imipramine in standard antidepressant assays in animals but showed no significant anticholinergic action and did not antagonize the antihypertensive effects of clonidine and guanethidine.Entities:
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Year: 1985 PMID： 3968690 DOI： 10.1021/jm00380a020
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446