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Literature DB >> 23624645

Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-₁Η-pyrazole-4-carbonitriles in green media.

Abstract

An efficient, one-pot, three-component synthesis of various biologically important heterocyclic compounds is described via a tandem Knoevengel-cyclo condensation reaction of aromatic aldehydes, malono derivatives, and phenyl hydrazine derivatives in water and ethanol at room temperature.

Entities: Chemical Gene

Mesh：

Substances：
Pyrazoles

Year: 2013 PMID： 23624645 DOI： 10.1007/s11030-013-9445-y

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

37 in total

1. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

Authors: T D Penning; J J Talley; S R Bertenshaw; J S Carter; P W Collins; S Docter; M J Graneto; L F Lee; J W Malecha; J M Miyashiro; R S Rogers; D J Rogier; S S Yu; E G Burton; J N Cogburn; S A Gregory; C M Koboldt; W E Perkins; K Seibert; A W Veenhuizen; Y Y Zhang; P C Isakson
Journal: J Med Chem Date: 1997-04-25 Impact factor: 7.446

2. Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.

Authors: Akihiko Tanitame; Yoshihiro Oyamada; Keiko Ofuji; Yoko Kyoya; Kenji Suzuki; Hideaki Ito; Motoji Kawasaki; Kazuo Nagai; Masaaki Wachi; Jun-ichi Yamagishi
Journal: Bioorg Med Chem Lett Date: 2004-06-07 Impact factor: 2.823

3. Efficient synthesis of pyrazoles: oxidative C-C/N-N bond-formation cascade.

Authors: Julia J Neumann; Mamta Suri; Frank Glorius
Journal: Angew Chem Int Ed Engl Date: 2010-10-11 Impact factor: 15.336

4. Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides.

Authors: Alice M R Bernardino; Adriana O Gomes; Karen S Charret; Antônio C C Freitas; Gérzia M C Machado; Marilene M Canto-Cavalheiro; Leonor L Leon; Veronica F Amaral
Journal: Eur J Med Chem Date: 2005-11-21 Impact factor: 6.514

5. Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents.

Authors: Sanjay Babu Katiyar; Kumkum Srivastava; S K Puri; Prem M S Chauhan
Journal: Bioorg Med Chem Lett Date: 2005-11-15 Impact factor: 2.823

6. Highly selective synthesis of pyrazole and spiropyrazoline phosphonates via base-assisted reaction of the Bestmann-Ohira reagent with enones.

Authors: Deepti Verma; Shaikh Mobin; Irishi N N Namboothiri
Journal: J Org Chem Date: 2011-05-03 Impact factor: 4.354

1. Synthesis of novel organosilicon compounds possessing highly substituted imidazole core catalyzed by antimony trioxide.

Authors: Kazem D Safa; Maryam Allahvirdinesbat; Hassan Namazi
Journal: Mol Divers Date: 2014-09-19 Impact factor: 2.943

1 in total

Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-₁Η-pyrazole-4-carbonitriles in green media.

1. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

2. Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.

3. Efficient synthesis of pyrazoles: oxidative C-C/N-N bond-formation cascade.

4. Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides.

5. Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents.

6. Highly selective synthesis of pyrazole and spiropyrazoline phosphonates via base-assisted reaction of the Bestmann-Ohira reagent with enones.

7. Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents.

8. 1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents.

9. In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug.

10. Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria.

1. Synthesis of novel organosilicon compounds possessing highly substituted imidazole core catalyzed by antimony trioxide.