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Literature DB >> 3956686

Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo.

Abstract

Dihalogenmethylenebisphosphonates increase alkaline phosphatase activity and fatty acid oxidation in calvaria cells in culture (Cl2MBP greater than Br2MBP approximately equal to F2MBP). The monohalogen ClMBP and the non-halogenated analogues are less active on phosphatase and inactive on or inhibitory towards fatty acid oxidation. The three dihalogenbisphosphonates and ClMBP inhibit bone resorption in vivo, Cl2MBP most strongly.

Entities: Chemical

Mesh：

Substances：

Year: 1986 PMID： 3956686 DOI： 10.1007/bf01942514

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

25 in total

1. Effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on rabbit articular chondrocytes in culture.

Authors: H L Guenther; H E Guenther; H Fleisch
Journal: Biochem J Date: 1979-11-15 Impact factor: 3.857

2. The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.

Authors: H A Fleisch; R G Russell; S Bisaz; R C Mühlbauer; D A Williams
Journal: Eur J Clin Invest Date: 1970-03 Impact factor: 4.686

Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo.

1. Effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on rabbit articular chondrocytes in culture.

2. The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.

3. Long term effects of dichloromethylene diphosphonate in Paget's disease of bone.

4. Increase in alkaline phosphatase activity in calvaria cells cultured with diphosphonates.

5. Relation between bone mineralization, Ca absorption, and plasma Ca in phosphonate-treated rats.

6. Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.

7. Sustained biochemical effects of short treatment of Paget's disease of bone with dichloromethylene diphosphonate.

8. Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo.

9. Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells.

10. Increase in fatty acid oxidation in calvaria cells cultured with diphosphonates.

1. Fatty acid oxidation in bone tissue and bone cells in culture. Characterization and hormonal influences.