Literature DB >> 5803538

Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo.

H Fleisch, R G Russell, M D Francis.   

Abstract

Two diphosphonates containing the P-C-P bond, Cl(2)C(PO(3)HNa)(2), and H(2)C(PO(3)HNa)(2) retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.

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Year:  1969        PMID： 5803538     DOI： 10.1126/science.165.3899.1262

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  164 in total

1.  Effect of gallium on the in vitro formation, growth, and solubility of hydroxyapatite.

Authors:  N C Blumenthal; V Cosma; S Levine
Journal:  Calcif Tissue Int       Date:  1989-08       Impact factor: 4.333

2.  On the pharmacological evaluation of bisphosphonates in humans.

Authors:  Serge Cremers; Frank Hal Ebetino; Roger Phipps
Journal:  Bone       Date:  2020-06-27       Impact factor: 4.398

Review 3.  Bisphosphonates in osteoporosis.

Authors:  H Fleisch
Journal:  Eur Spine J       Date:  2003-09-16       Impact factor: 3.134

Review 4.  Treatment of multiple myeloma in elderly patients. New developments.

Authors:  G J Ossenkoppele
Journal:  Drugs Aging       Date:  1997-08       Impact factor: 3.923

5.  Effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on rabbit articular chondrocytes in culture.

Authors:  H L Guenther; H E Guenther; H Fleisch
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

6.  Calcium balance in children treated with diphosphonates.

Authors:  W S Uttley; N R Belton; J Syme; H Sheppard
Journal:  Arch Dis Child       Date:  1975-03       Impact factor: 3.791

7.  Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin.

Authors:  Z Zimolo; G Wesolowski; G A Rodan
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808

8.  Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increase macrophages, granulocytes, and osteoclasts in vivo.

Authors:  Y Endo; M Nakamura; T Kikuchi; H Shinoda; Y Takeda; Y Nitta; K Kumagai
Journal:  Calcif Tissue Int       Date:  1993-03       Impact factor: 4.333

Review 9.  New bisphosphonates in osteoporosis.

Authors:  H Fleisch
Journal:  Osteoporos Int       Date:  1993       Impact factor: 4.507

10.  Bisphosphonates act on rat bone resorption through the mediation of osteoblasts.

Authors:  M Sahni; H L Guenther; H Fleisch; P Collin; T J Martin
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808
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