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Literature DB >> 6459147

Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells.

Abstract

The calvaria cells cultured for 6 days in the presence of dichloromethanediphosphonate (Cl2MDP) (0.025-250 microM), the synthesis of prostaglandin E2 (PGE2) was inhibited by up to 90%. Inhibition of PGE2 synthesis might be one mechanism whereby this diphosphonate inhibits bone resorption. This effect is not common to all diphosphates since 25 microM 3-amino-1-hydroxypropane-1,1-diphosphonate (AHPDP) stimulated the synthesis of PGE2.

Entities: Chemical

Mesh：

Substances：

Year: 1981 PMID： 6459147 DOI： 10.1007/bf02409488

Source DB: PubMed Journal: Calcif Tissue Int ISSN： 0171-967X Impact factor: 4.333

20 in total

1. Effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on rabbit articular chondrocytes in culture.

Authors: H L Guenther; H E Guenther; H Fleisch
Journal: Biochem J Date: 1979-11-15 Impact factor: 3.857

2. Stimulation of prostaglandin biosynthesis by vasoactive substances in methylcholanthrene-transformed mouse BALB/3T3.

Authors: S L Hong; R Polsky-Cynkin; L Levine
Journal: J Biol Chem Date: 1976-02-10 Impact factor: 5.157

3. The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.

Authors: H A Fleisch; R G Russell; S Bisaz; R C Mühlbauer; D A Williams
Journal: Eur J Clin Invest Date: 1970-03 Impact factor: 4.686

4. Treatment of Paget's disease with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.).

Authors: W B Frijlink; O L Bijvoet; J te Velde; G Heynen
Journal: Lancet Date: 1979-04-14 Impact factor: 79.321

5. Influence of disodium etidronate on clinical and laboratory manifestations of Paget's disease of bone (osteitis deformans).

Authors: R D Altman; C C Johnston; M R Khairi; H Wellman; A N Serafini; R R Sankey
Journal: N Engl J Med Date: 1973-12-27 Impact factor: 91.245

6. Increase in alkaline phosphatase activity in calvaria cells cultured with diphosphonates.

Authors: R Felix; H Fleisch
Journal: Biochem J Date: 1979-10-01 Impact factor: 3.857

7. Complement-dependent stimulation of prostaglandin synthesis and bone resorption.

Authors: L G Raisz; A L Sandberg; J M Goodson; H A Simmons; S E Mergenhagen
Journal: Science Date: 1974-08-30 Impact factor: 47.728

8. Effects of dichloromethylene diphosphonate on skeletal mobilization of calcium in multiple myeloma.

Authors: E S Siris; W H Sherman; D C Baquiran; J P Schlatterer; E F Osserman; R E Canfield
Journal: N Engl J Med Date: 1980-02-07 Impact factor: 91.245

9. Effect of diphosphonates on glycogen content of rabbit ear cartilage cells in culture.

Authors: R Felix; D K Fast; J D Sallis; H Fleisch
Journal: Calcif Tissue Int Date: 1980 Impact factor: 4.333

10. Inhibition of osteolytic bone lesions by (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.).

Authors: F J van Breukelen; O L Bijvoet; A T van Oosterom
Journal: Lancet Date: 1979-04-14 Impact factor: 79.321

9 in total

Review 1. Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease.

Authors: H Fleisch
Journal: Drugs Date: 1991-12 Impact factor: 9.546

2. Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.

Authors: M Sato; W Grasser; N Endo; R Akins; H Simmons; D D Thompson; E Golub; G A Rodan
Journal: J Clin Invest Date: 1991-12 Impact factor: 14.808

3. Bisphosphonates inhibit 1,25-dihydroxyvitamin D3-induced increase of osteocalcin in plasma of rats in vivo and in culture medium of rat calvaria in vitro.

Authors: S A Stronski; L Bettschen-Camin; A Wetterwald; R Felix; U Trechsel; H Fleisch
Journal: Calcif Tissue Int Date: 1988-04 Impact factor: 4.333

4. Pamidronate in patients with painful bone metastases, who failed initial treatment with hormones and/or chemotherapy.

Authors: S Cascinu; V Casadei; E Del Ferro; P Alessandroni; G Catalano
Journal: Support Care Cancer Date: 1996-01 Impact factor: 3.603

Review 5. Use of bisphosphonates for the treatment of stress fractures in athletes.

Authors: Yosuke Shima; Lars Engebretsen; Junji Iwasa; Katsuhiko Kitaoka; Katsuro Tomita
Journal: Knee Surg Sports Traumatol Arthrosc Date: 2008-12-02 Impact factor: 4.342

6. Influence of dichloromethylene bisphosphonate on the in vitro phagocytosis of hydroxyapatite particles by rat peritoneal exudate cells: an electron microscopic and chemiluminescence study.

Authors: P M Hyvönen; M J Kowolik
Journal: Ann Rheum Dis Date: 1992-02 Impact factor: 19.103