| Literature DB >> 4308521 |
M D Francis, R G Russell, H Fleisch.
Abstract
Two diphosphonates containing the P-C-P bond, CH(3)C(OH)(PO(3)HNa)(2) and H(2)C(PO(3)HNa)(2), inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification of rats given large amounts of vitamin D(3). The diphosphonates therefore have effects similar to those described for compounds containing the P-O-P bond but are active when administered orally.Entities:
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Year: 1969 PMID： 4308521 DOI： 10.1126/science.165.3899.1264
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728