Literature DB >> 3877892

Development of a 99Tcm-labelled radiopharmaceutical for cerebral blood flow imaging.

D P Nowotnik, L R Canning, S A Cumming, R C Harrison, B Higley, G Nechvatal, R D Pickett, I M Piper, V J Bayne, A M Forster.   

Abstract

A new radiopharmaceutical, 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO) has shown considerable promise for single photon emission tomographic (SPECT) imaging of the brain. In animal biodistribution studies this complex demonstrates good brain uptake with prolonged retention of activity in brain. Further improvement of these properties, resulting in higher brain uptake with very slow washout and fixed regional distribution has been achieved following the isolation of the d,1-diastereoisomer of HM-PAO.

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Year:  1985        PMID： 3877892     DOI： 10.1097/00006231-198509000-00002

Source DB:  PubMed          Journal:  Nucl Med Commun        ISSN： 0143-3636            Impact factor:   1.690


  18 in total

1.  Motor stimulation response by technetium-99m hexamethylpropylene amine oxime split-dose method and single photon emission tomography.

Authors:  P Pantano; V Di Piero; M Ricci; C Fieschi; L Bozzao; G L Lenzi
Journal:  Eur J Nucl Med       Date:  1992

2.  99mTc-hexamethylpropylene amine oxime SPECT and X-ray CT in acute cerebral ischaemia.

Authors:  M Feldmann; E Voth; D Dressler; T Henze; K Felgenhauer
Journal:  J Neurol       Date:  1990-12       Impact factor: 4.849

Review 3.  A brief overview of metal complexes as nuclear imaging agents.

Authors:  Douglas S MacPherson; Kimberly Fung; Brendon E Cook; Lynn C Francesconi; Brian M Zeglis
Journal:  Dalton Trans       Date:  2019-10-07       Impact factor: 4.390

4.  Case report: regional cerebral hypoperfusion induced by ventricular tachycardia - short-term hippocampal hypoperfusion and its potential relationship to selective neuronal damage.

Authors:  A Hagendorff; E Klemm; M Bangard; C Dettmers; C Wolpert; B Schumacher; H J Biersack; F Grünwald; B Lüderitz; D Pfeiffer
Journal:  J Interv Card Electrophysiol       Date:  2001-12       Impact factor: 1.900

5.  Single photon emission computed tomography with 99mTc HM-PAO in the study of focal epilepsy.

Authors:  E Grasso; L Ambrogio; A Cognazzo; P C Gerbino-Promis; P Zagnoni; G F Camuzzini; A Papaleo; F Acchiardi; G Perno
Journal:  Ital J Neurol Sci       Date:  1989-04

Review 6.  Clinical applications of SPECT.

Authors:  J W Keyes
Journal:  Int J Card Imaging       Date:  1989

7.  99mTc-HMPAO as a tumour blood flow agent.

Authors:  P A Hammersley; V R McCready; J W Babich; G Coghlan
Journal:  Eur J Nucl Med       Date:  1987

8.  An evaluation of 99mTc-HMPAO uptake in cerebral gliomas--a comparison with X-ray CT.

Authors:  A T Irvine; M A Flower; R J Ott; J W Babich; F Kabir; V R McCready
Journal:  Eur J Nucl Med       Date:  1990

9.  Quantification of technetium-99m hexamethylpropylene amine oxime brain uptake in routine clinical practice using calibrated point sources as an external standard: phantom and human studies.

Authors:  A Dobbeleir; R Dierckx
Journal:  Eur J Nucl Med       Date:  1993-08

10.  Evaluation of brain SPECT in the diagnosis and prognosis of the normal pressure hydrocephalus syndrome.

Authors:  J M Granado; F Diaz; R Alday
Journal:  Acta Neurochir (Wien)       Date:  1991       Impact factor: 2.216
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