Literature DB >> 3862088

Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer.

K Shimizu, Y Nakatsu, M Sekiguchi, K Hokamura, K Tanaka, M Terada, T Sugimura.   

Abstract

Transfection with high molecular weight DNA from a primary stomach cancer induced foci of transformed NIH 3T3 cells, and the transformed cells were tumorigenic in nude mice. By screening with a human Alu-family probe, we isolated the human DNA sequence from the secondary transformant cells. This transforming sequence encompasses about 60 kilobase pairs and is unrelated to known human transforming genes. Examination of homologies between this sequence and retroviral oncogenes revealed that the human transforming sequence is closely related to the v-raf oncogene of murine transforming retrovirus 3611-MSV.

Entities:  

Mesh：

Year:  1985        PMID： 3862088      PMCID： PMC390607          DOI： 10.1073/pnas.82.17.5641

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  The transformation of Escherichia coli with deoxyribonucleic acid isolated from bacteriophage lambda-dg.

Authors:  A D KAISER; D S HOGNESS
Journal:  J Mol Biol       Date:  1960-12       Impact factor: 5.469

2.  Transformation of mammalian cells with genes from procaryotes and eucaryotes.

Authors:  M Wigler; R Sweet; G K Sim; B Wold; A Pellicer; E Lacy; T Maniatis; S Silverstein; R Axel
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

3.  Structure and activation of the human N-ras gene.

Authors:  E Taparowsky; K Shimizu; M Goldfarb; M Wigler
Journal:  Cell       Date:  1983-09       Impact factor: 41.582

4.  A small cosmid for efficient cloning of large DNA fragments.

Authors:  B Hohn; J Collins
Journal:  Gene       Date:  1980-11       Impact factor: 3.688

5.  Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

Authors:  C J Der; T G Krontiris; G M Cooper
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

6.  Molecular cloning of a new transforming gene from a chemically transformed human cell line.

Authors:  C S Cooper; M Park; D G Blair; M A Tainsky; K Huebner; C M Croce; G F Vande Woude
Journal:  Nature       Date:  1984 Sep 6-11       Impact factor: 49.962

7.  Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells.

Authors:  J L Jainchill; S A Aaronson; G J Todaro
Journal:  J Virol       Date:  1969-11       Impact factor: 5.103

8.  Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

Authors:  U R Rapp; M D Goldsborough; G E Mark; T I Bonner; J Groffen; F H Reynolds; J R Stephenson
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

9.  New mammalian transforming retrovirus: demonstration of a polyprotein gene product.

Authors:  U R Rapp; F H Reynolds; J R Stephenson
Journal:  J Virol       Date:  1983-03       Impact factor: 5.103

10.  Kidney carcinomas of the fowl induced by the MH2 reticuloendothelioma virus.

Authors:  J G CARR
Journal:  Br J Cancer       Date:  1960-03       Impact factor: 7.640
View more
  37 in total

1.  Structure and transforming potential of the human cot oncogene encoding a putative protein kinase.

Authors:  J Miyoshi; T Higashi; H Mukai; T Ohuchi; T Kakunaga
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

2.  Autoregulation of the Raf-1 serine/threonine kinase.

Authors:  R E Cutler; R M Stephens; M R Saracino; D K Morrison
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

3.  Induction of transformation and DNA synthesis after microinjection of raf proteins.

Authors:  M R Smith; G Heidecker; U R Rapp; H F Kung
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

4.  B-raf, a new member of the raf family, is activated by DNA rearrangement.

Authors:  S Ikawa; M Fukui; Y Ueyama; N Tamaoki; T Yamamoto; K Toyoshima
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

5.  The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.

Authors:  T I Bonner; H Oppermann; P Seeburg; S B Kerby; M A Gunnell; A C Young; U R Rapp
Journal:  Nucleic Acids Res       Date:  1986-01-24       Impact factor: 16.971

6.  Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

Authors:  V P Stanton; D W Nichols; A P Laudano; G M Cooper
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

7.  The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions.

Authors:  N R Soman; P Correa; B A Ruiz; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

8.  Tumorigenicity of simian virus 40-hepatocyte cell lines: effect of in vitro and in vivo passage on expression of liver-specific genes and oncogenes.

Authors:  C D Woodworth; J W Kreider; L Mengel; T Miller; Y L Meng; H C Isom
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

9.  Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.

Authors:  K Huebner; A ar-Rushdi; C A Griffin; M Isobe; C Kozak; B S Emanuel; L Nagarajan; J L Cleveland; T I Bonner; M D Goldsborough
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

10.  Rat c-raf oncogene activation by a rearrangement that produces a fused protein.

Authors:  F Ishikawa; F Takaku; M Nagao; T Sugimura
Journal:  Mol Cell Biol       Date:  1987-03       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.