Literature DB >> 3855838

Association between a genetic trait and a marker: discrimination between epistasis and gametic disequilibrium.

F Clerget-Darpoux, G M Lathrop.   

Abstract

We reconsider the method of Ott and Falk (1982) for the analysis of genetic linkage and of epistasis in the presence of phenotypic association. Their approach is extended to allow for gametic disequilibrium between marker and trait loci. We show that epistasis and tight linkage with gametic disequilibrium may be indistinguishable as explanations of association even in a very large pedigree.

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Year:  1985        PMID： 3855838     DOI： 10.1007/bf00293296

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  7 in total

1.  Linkage relationships of Lp and Ag serum lipoproteins with 25 polymorphic markers.

Authors:  K K Namboodiri; R C Elston; R C Go; K Berg; C Hames
Journal:  Hum Genet       Date:  1977-07-26       Impact factor: 4.132

2.  Bias of the estimated recombination fraction and lod score due to an association between a disease gene and a marker gene.

Authors:  F Clerget-Darpoux
Journal:  Ann Hum Genet       Date:  1982-10       Impact factor: 1.670

3.  Some epistatic two-locus models of disease. II. The confounding of linkage and association.

Authors:  S E Hodge; M A Spence
Journal:  Am J Hum Genet       Date:  1981-05       Impact factor: 11.025

4.  Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated diseases.

Authors:  F Clerget-Darpoux; C Bonaïti-Pellié
Journal:  Ann Hum Genet       Date:  1980-10       Impact factor: 1.670

5.  Epistatic association and linkage analysis in human families.

Authors:  J Ott; C T Falk
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

6.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

7.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205
  7 in total
  1 in total

1.  2017 Presidential Address: Checking, Balancing, and Celebrating Diversity: Celebrating Some of the Women Who Paved the Way.

Authors:  Nancy J Cox
Journal:  Am J Hum Genet       Date:  2018-03-01       Impact factor: 11.025
  1 in total

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