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Literature DB >> 6941696

Some epistatic two-locus models of disease. II. The confounding of linkage and association.

Abstract

This paper continues to examine the model discussed in the preceding paper. Specifically, it will be shown how a linkage analysis performed in the presence of a disease-marker association can give rise to erroneous and misleading results.

Mesh：

Substances：

Year: 1981 PMID： 6941696 PMCID： PMC1685039

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

12 in total

Review 1. HLA, ankylosing spondylitis and rheumatoid arthritis.

Authors: J A Sachs; D A Brewerton
Journal: Br Med Bull Date: 1978-09 Impact factor: 4.291

2. Is juvenile diabetes determined by a single gene closely linked to HLA?

Authors: B Suarez; S E Hodge; T Reich
Journal: Diabetes Date: 1979-06 Impact factor: 9.461

3. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors: J Ott
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

4. Evidence for a specific B27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis.

Authors: K Seager; H V Bashir; A F Geczy; J Edmonds; A de Vere-Tyndall
Journal: Nature Date: 1979-01-04 Impact factor: 49.962

5. Hypertrophic cardiomyopathy.

Authors: S E Hodge; M A Spence; S D Cederbaum
Journal: N Engl J Med Date: 1979-08-23 Impact factor: 91.245

6. Hypertrophic cardiomyopathy and human leukocyte antigen linkage: differentiation of two forms of hypertrophic cardiomyopathy.

Authors: J R Darsee; S B Heymsfield; D O Nutter
Journal: N Engl J Med Date: 1979-04-19 Impact factor: 91.245

7. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease.

Authors: R W Ebringer; D R Cawdell; P Cowling; A Ebringer
Journal: Ann Rheum Dis Date: 1978-04 Impact factor: 19.103

8. Analysis of linkage between the major histocompatibility system and juvenile, insulin-dependent diabetes in multiplex families. Reanalysis of data.

Authors: J Barbosa; M M Chern; H Noreen; V E Anderson
Journal: J Clin Invest Date: 1978-08 Impact factor: 14.808

9. HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees.

Authors: J L Tiwari; S E Hodge; P I Terasaki; M A Spence
Journal: Am J Hum Genet Date: 1980-01 Impact factor: 11.025

10. Genetic linkage between hereditary hemochromatosis and HLA.

Authors: K Kravitz; M Skolnick; C Cannings; D Carmelli; B Baty; B Amos; A Johnson; N Mendell; C Edwards; G Cartwright
Journal: Am J Hum Genet Date: 1979-09 Impact factor: 11.025

14 in total

1. Estimation of segregation and linkage parameters in simulated data. II. Simultaneous estimation with one linked marker.

Authors: R A Price; P L Kramer; D L Pauls; K K Kidd
Journal: Am J Hum Genet Date: 1989-07 Impact factor: 11.025

8. Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.

Authors: S E Hodge
Journal: Am J Hum Genet Date: 1981-05 Impact factor: 11.025

9. Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.

Authors: S E Hodge
Journal: Am J Hum Genet Date: 1993-08 Impact factor: 11.025

10. The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.

Authors: S E Hodge; C E Anderson; K Neiswanger; R S Sparkes; D L Rimoin
Journal: Am J Hum Genet Date: 1983-11 Impact factor: 11.025