Literature DB >> 3822814

Cell cycle regulated synthesis of stable mouse thymidine kinase mRNA is mediated by a sequence within the cDNA.

R Hofbauer, E Müllner, C Seiser, E Wintersberger.   

Abstract

The cDNA for mouse thymidine kinase (TK) was isolated from a cDNA library in lambda-gt11 and sequenced. It was used as a probe to follow the time course of TK mRNA expression in growth stimulated mouse fibroblasts. Linked to the HSV-TK promoter the cDNA was able to transform LTK-cells to the TK+ phenotype. The transformed cells expressed the TK mRNA and enzyme activity in a growth dependent fashion suggesting that the regulatory element is localized on the cDNA.

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Year:  1987        PMID： 3822814      PMCID： PMC340464          DOI： 10.1093/nar/15.2.741

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  25 in total

1.  Thymidine kinase isozymes of normal and virus-infected cells.

Authors:  S Kit; W C Leung; G N Jorgensen; D Trkula; D R Dubbs
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1975

2.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

3.  Thymidine kinase, DNA synthesis and cancer.

Authors:  S Kit
Journal:  Mol Cell Biochem       Date:  1976-06-15       Impact factor: 3.396

4.  Genetic determinants of growth phase-dependent and adenovirus 5-responsive expression of the Chinese hamster thymidine kinase gene are contained within thymidine kinase mRNA sequences.

Authors:  J A Lewis; D A Matkovich
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

5.  Regulation of thymidine kinase enzyme level in serum-stimulated mouse 3T6 fibroblasts.

Authors:  L F Johnson; L G Rao; A J Muench
Journal:  Exp Cell Res       Date:  1982-03       Impact factor: 3.905

6.  Cell cycle-dependent regulation of thymidine kinase activity introduced into mouse LMTK- cells by DNA and chromatin-mediated gene transfer.

Authors:  C A Schlosser; C Steglich; J R deWet; I E Scheffler
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Human deoxythymidine kinase II: substrate specificity and kinetic behavior of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia.

Authors:  L S Lee; Y c Cheng
Journal:  Biochemistry       Date:  1976-08-24       Impact factor: 3.162

9.  Effect of sodium butyrate on induction of cellular and viral DNA syntheses in polyoma virus-infected mouse kidney cells.

Authors:  E Wawra; E Pöckl; E Müllner; E Wintersberger
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  20 in total

1.  Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.

Authors:  S Bartl; J Taplick; G Lagger; H Khier; K Kuchler; C Seiser
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  Identification of a 70-base-pair cell cycle regulatory unit within the promoter of the human thymidine kinase gene and its interaction with cellular factors.

Authors:  Y K Kim; A S Lee
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

3.  Ordered splicing of thymidine kinase pre-mRNA during the S phase of the cell cycle.

Authors:  J M Gudas; G B Knight; A B Pardee
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

4.  S-phase-specific regulation by deletion mutants of the human thymidine kinase promoter.

Authors:  K E Lipson; S T Chen; J Koniecki; D H Ku; R Baserga
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

5.  Mouse thymidine kinase: the promoter sequence and the gene and pseudogene structures in normal cells and in thymidine kinase deficient mutants.

Authors:  C Seiser; M Knöfler; I Rudelstorfer; R Haas; E Wintersberger
Journal:  Nucleic Acids Res       Date:  1989-01-11       Impact factor: 16.971

6.  Thymidine kinase synthesis is repressed in nonreplicating muscle cells by a translational mechanism that does not affect the polysomal distribution of thymidine kinase mRNA.

Authors:  M K Gross; G F Merrill
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

7.  Preproenkephalin mRNA expression in developing rat heart and in cultured ventricular cardiac muscle cells.

Authors:  J P Springhorn; W C Claycomb
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

8.  Introns are inconsequential to efficient formation of cellular thymidine kinase mRNA in mouse L cells.

Authors:  M K Gross; M S Kainz; G F Merrill
Journal:  Mol Cell Biol       Date:  1987-12       Impact factor: 4.272

9.  Transcriptional and posttranscriptional mechanisms regulate murine thymidine kinase gene expression in serum-stimulated cells.

Authors:  H B Lieberman; P F Lin; D B Yeh; F H Ruddle
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

10.  Presence of regulatory sequences within intron 2 of the mouse thymidine kinase gene.

Authors:  H Rotheneder; M Grabner; E Wintersberger
Journal:  Nucleic Acids Res       Date:  1991-12-25       Impact factor: 16.971
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