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Literature DB >> 3821733

Characterization of the rearranged tpr-met oncogene breakpoint.

Abstract

We determined the nucleotide sequence of the rearranged trp-met genomic locus and the corresponding portions of the unrearranged tpr and met genomic fragments. The breakpoints occur at one end of a stretch of 21 A residues that follow an Alu repetitive sequence in the tpr locus and within a group of 3 A residues in the met proto-oncogene locus. We conclude that the fusion between the tpr locus on chromosome 1 and the met locus on chromosome 7 resulted from a recombination event.

Entities: Chemical Gene

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Year: 1987 PMID： 3821733 PMCID： PMC365151 DOI： 10.1128/mcb.7.2.921-924.1987

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

29 in total

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Journal: Nature Date: 1975-08-28 Impact factor: 49.962

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Journal: J Mol Biol Date: 1977-06-15 Impact factor: 5.469

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Authors: W D Benton; R W Davis
Journal: Science Date: 1977-04-08 Impact factor: 47.728

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Journal: Nature Date: 1982-04-01 Impact factor: 49.962

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Journal: Nature Date: 1981-01-29 Impact factor: 49.962

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Authors: P Perry; H J Evans
Journal: Nature Date: 1975-11-13 Impact factor: 49.962

9. Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation.

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Journal: Biochem J Date: 1970-02 Impact factor: 3.857

10. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

21 in total

1. C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition.

Authors: A Cannistraci; G Federici; A Addario; A L Di Pace; L Grassi; G Muto; D Collura; M Signore; L De Salvo; S Sentinelli; G Simone; M Costantini; S Nanni; A Farsetti; V Coppola; R De Maria; D Bonci
Journal: Oncogene Date: 2017-02-13 Impact factor: 9.867

2. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor.

Authors: H Takayama; W J LaRochelle; R Sharp; T Otsuka; P Kriebel; M Anver; S A Aaronson; G Merlino
Journal: Proc Natl Acad Sci U S A Date: 1997-01-21 Impact factor: 11.205

3. Localization of preferential sites of rearrangement within the BCR gene in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Authors: C T Denny; N P Shah; S Ogden; C Willman; T McConnell; W Crist; A Carroll; O N Witte
Journal: Proc Natl Acad Sci U S A Date: 1989-06 Impact factor: 11.205

4. Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.

Authors: Kuntal Pal; Abhishek Bandyopadhyay; X Edward Zhou; Qingping Xu; David P Marciano; Joseph S Brunzelle; Smitha Yerrum; Patrick R Griffin; George Vande Woude; Karsten Melcher; H Eric Xu
Journal: Structure Date: 2017-05-18 Impact factor: 5.006

5. Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of the BCR gene.

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Journal: Nucleic Acids Res Date: 1989-01-11 Impact factor: 16.971

Review 6. Biology of MET: a double life between normal tissue repair and tumor progression.

Authors: Iacopo Petrini
Journal: Ann Transl Med Date: 2015-04

7. C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells.

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Journal: Clin Exp Metastasis Date: 1998-04 Impact factor: 5.150

8. Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis.

Authors: T Otsuka; J Jakubczak; W Vieira; D P Bottaro; D Breckenridge; W J Larochelle; G Merlino
Journal: Mol Cell Biol Date: 2000-03 Impact factor: 4.272

Review 9. Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease.

Authors: Stefanie Gerstberger; Markus Hafner; Manuel Ascano; Thomas Tuschl
Journal: Adv Exp Med Biol Date: 2014 Impact factor: 2.622

10. Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

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Journal: Proc Natl Acad Sci U S A Date: 1988-01 Impact factor: 11.205