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Literature DB >> 6258076

The origin of human cancers.

Abstract

The limited evidence available suggests that most human cancers are not caused by conventional mutagens but are more likely to be the result of genetic transpositions. Although the molecular biology of transposition is starting to be understood, the external factors that influence its frequency have not yet been studied in any detail.

Entities: Disease Species

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Year: 1981 PMID： 6258076 DOI： 10.1038/289353a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

112 in total

Review 1. Expression patterns of cellular growth-controlling genes in non-medullary thyroid cancer: basic aspects.

Authors: N J Sarlis
Journal: Rev Endocr Metab Disord Date: 2000-04 Impact factor: 6.514

2. Clonal dynamics of progressive neoplastic transformation.

Authors: M Chow; H Rubin
Journal: Proc Natl Acad Sci U S A Date: 1999-06-08 Impact factor: 11.205

3. Stochastic elimination of cancer cells.

Authors: Franziska Michor; Martin A Nowak; Steven A Frank; Yoh Iwasa
Journal: Proc Biol Sci Date: 2003-10-07 Impact factor: 5.349

4. The stem cells of the liver--a selective review.

Authors: K Aterman
Journal: J Cancer Res Clin Oncol Date: 1992 Impact factor: 4.553

5. Inhibitor-associated transposition events in Corynebacterium glutamicum.

Authors: T R Garbe; N Suzuki; M Inui; H Yukawa
Journal: Mol Genet Genomics Date: 2004-06-18 Impact factor: 3.291

6. "Rogue" lymphocytes among Ukrainians not exposed to radioactive fall-out from the Chernobyl accident: the possible role of this phenomenon in oncogenesis, teratogenesis, and mutagenesis.

Authors: J V Neel; A A Awa; Y Kodama; M Nakano; K Mabuchi
Journal: Proc Natl Acad Sci U S A Date: 1992-08-01 Impact factor: 11.205

The origin of human cancers.

Review 1. Expression patterns of cellular growth-controlling genes in non-medullary thyroid cancer: basic aspects.

2. Clonal dynamics of progressive neoplastic transformation.

3. Stochastic elimination of cancer cells.

4. The stem cells of the liver--a selective review.

5. Inhibitor-associated transposition events in Corynebacterium glutamicum.

6. "Rogue" lymphocytes among Ukrainians not exposed to radioactive fall-out from the Chernobyl accident: the possible role of this phenomenon in oncogenesis, teratogenesis, and mutagenesis.

7. Homologous plasmid recombination is elevated in immortally transformed cells.

Review 8. Chemical carcinogenesis -- the price for DNA - repair?

Review 9. Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

Review 10. Clinical and biological significance of aneuploidy in human tumours.