Literature DB >> 3796599

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.

D W Shen, A Fojo, I B Roninson, J E Chin, R Soffir, I Pastan, M M Gottesman.   

Abstract

Mouse NIH 3T3 cells were transformed to multidrug resistance with high-molecular-weight DNA from multidrug-resistant human KB carcinoma cells. The patterns of cross resistance to colchicine, vinblastine, and doxorubicin hydrochloride (Adriamycin; Adria Laboratories Inc.) of the human donor cell line and mouse recipients were similar. The multidrug-resistant human donor cell line contains amplified sequences of the mdr1 gene which are expressed at high levels. Both primary and secondary NIH 3T3 transformants contained and expressed these amplified human mdr1 sequences. Amplification and expression of the human mdr1 sequences and amplification of cotransferred human Alu sequences in the mouse cells correlated with the degree of multidrug resistance. These data suggest that the mdr1 gene is likely to be responsible for multidrug resistance in cultured cells.

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Year:  1986        PMID： 3796599      PMCID： PMC367169          DOI： 10.1128/mcb.6.11.4039-4045.1986

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  25 in total

1.  Transformation of mammalian cells with genes from procaryotes and eucaryotes.

Authors:  M Wigler; R Sweet; G K Sim; B Wold; A Pellicer; E Lacy; T Maniatis; S Silverstein; R Axel
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

2.  A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.

Authors:  R L Juliano; V Ling
Journal:  Biochim Biophys Acta       Date:  1976-11-11

3.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

4.  Localization of multidrug resistance-associated DNA sequences to human chromosome 7.

Authors:  A Fojo; R Lebo; N Shimizu; J E Chin; I B Roninson; G T Merlino; M M Gottesman; I Pastan
Journal:  Somat Cell Mol Genet       Date:  1986-07

5.  A rapid alkaline extraction procedure for screening recombinant plasmid DNA.

Authors:  H C Birnboim; J Doly
Journal:  Nucleic Acids Res       Date:  1979-11-24       Impact factor: 16.971

6.  Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

Authors:  W T Beck; T J Mueller; L R Tanzer
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

7.  Base sequence studies of 300 nucleotide renatured repeated human DNA clones.

Authors:  P L Deininger; D J Jolly; C M Rubin; T Friedmann; C W Schmid
Journal:  J Mol Biol       Date:  1981-09-05       Impact factor: 5.469

8.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors:  P J Southern; P Berg
Journal:  J Mol Appl Genet       Date:  1982

9.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  41 in total

Review 1.  Genetic aspects of multidrug resistance.

Authors:  M Pauly; F Ries; M Dicato
Journal:  Med Oncol Tumor Pharmacother       Date:  1992

2.  Functional rescue of a misfolded eukaryotic ATP-binding cassette transporter by domain replacement.

Authors:  Raymond J Louie; Silvere Pagant; Ji-Young Youn; John J Halliday; Gregory Huyer; Susan Michaelis; Elizabeth A Miller
Journal:  J Biol Chem       Date:  2010-09-14       Impact factor: 5.157

3.  Expression of a multidrug-resistance gene in human tumors and tissues.

Authors:  A T Fojo; K Ueda; D J Slamon; D G Poplack; M M Gottesman; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

Review 4.  The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells.

Authors:  L O'Driscoll; C Daly; M Saleh; M Clynes
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

5.  In vivo etoposide-resistant C6 glioma cell line: significance of altered DNA topoisomerase II activity in multi-drug resistance.

Authors:  T Taki; T Ohnishi; N Arita; S Hiraga; T Hayakawa
Journal:  J Neurooncol       Date:  1998-01       Impact factor: 4.130

6.  Structure and expression of the human MDR (P-glycoprotein) gene family.

Authors:  J E Chin; R Soffir; K E Noonan; K Choi; I B Roninson
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

Review 7.  From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors.

Authors:  Metin Kurtoglu; Theodore J Lampidis
Journal:  Mol Nutr Food Res       Date:  2009-01       Impact factor: 5.914

8.  Effect of cyclosporin A on daunorubicin accumulation in multidrug-resistant P388 leukemia cells measured by real-time flow cytometry.

Authors:  K Nooter; R Oostrum; R Jonker; H van Dekken; W Stokdijk; G van den Engh
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

9.  Cloning and regulation of the rat mdr2 gene.

Authors:  P C Brown; S S Thorgeirsson; J A Silverman
Journal:  Nucleic Acids Res       Date:  1993-08-11       Impact factor: 16.971

10.  Isolation and characterization of additional genes influencing resistance to various mutagens in the yeast Saccharomyces cerevisiae.

Authors:  E Haase; J Servos; M Brendel
Journal:  Curr Genet       Date:  1992-04       Impact factor: 3.886
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