Literature DB >> 1364127

Genetic aspects of multidrug resistance.

M Pauly1, F Ries, M Dicato.   

Abstract

Gene amplification is responsible both for dihydrofolate reductase induced methotrexate resistance, and for the P-glycoprotein encoding multigene family induced multidrug resistance. The 6 pairs of hydrophobic regions of the P-glycoprotein fold up in a snake-like structure through the lipidic layers of the cell membrane. Other detoxification mechanisms include the glutathione S-transferase 'pi', but without gene amplification.

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Year:  1992        PMID： 1364127     DOI： 10.1007/bf02989649

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  21 in total

1.  Amplification and expression of genes associated with multidrug resistance in mammalian cells.

Authors:  K W Scotto; J L Biedler; P W Melera
Journal:  Science       Date:  1986-05-09       Impact factor: 47.728

2.  RFLPs associated with MDR2, a member of the human multidrug resistance gene family mapped to chromosome 7.

Authors:  K Choi; L E Hake; A M Bowcock; I B Roninson; L L Cavalli-Sforza
Journal:  Nucleic Acids Res       Date:  1987-08-11       Impact factor: 16.971

3.  Treatment of advanced and refractory breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial.

Authors:  F Ries; M Dicato
Journal:  Med Oncol Tumor Pharmacother       Date:  1991

4.  Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.

Authors:  J A Moscow; A J Townsend; M E Goldsmith; J Whang-Peng; P J Vickers; R Poisson; S Legault-Poisson; C E Myers; K H Cowan
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

5.  Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

Authors:  W S Dalton; T M Grogan; P S Meltzer; R J Scheper; B G Durie; C W Taylor; T P Miller; S E Salmon
Journal:  J Clin Oncol       Date:  1989-04       Impact factor: 44.544

6.  Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.

Authors:  J R Riordan; K Deuchars; N Kartner; N Alon; J Trent; V Ling
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

7.  Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.

Authors:  D W Shen; A Fojo; I B Roninson; J E Chin; R Soffir; I Pastan; M M Gottesman
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

8.  Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

Authors:  R F Ozols; R E Cunnion; R W Klecker; T C Hamilton; Y Ostchega; J E Parrillo; R C Young
Journal:  J Clin Oncol       Date:  1987-04       Impact factor: 44.544

9.  A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo.

Authors:  P J Vickers; R B Dickson; R Shoemaker; K H Cowan
Journal:  Mol Endocrinol       Date:  1988-10

10.  Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

Authors:  D W Shen; A Fojo; J E Chin; I B Roninson; N Richert; I Pastan; M M Gottesman
Journal:  Science       Date:  1986-05-02       Impact factor: 47.728
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