Literature DB >> 3793108

The effect of 1-beta-D-arabinofuranosyl-cytosine on the expression of the common fragile site at 3p14.

X Z Li, Z A Yan, X T Zhou.   

Abstract

The effect of the G2-treatment of 1-beta-D-arabino-furanosyl-cytosine (araC) on the expression of the common fragile site at 3p14 (FRA3B) was studied. A significantly increased frequency of FRA3B induced by G2 treatment of araC was found in the lymphocytes grown in folate-deficient medium (positive rate 100%). A relatively low frequency of FRA3B was also induced in the cultures with folate in four of the seven subjects. There is a synergistic effect between araC and growth in folate-deficient medium on the induction of FRA3B. The results suggest that the DNA lesions related to the expression of FRA3B induce the long-patch repair and that the low DNA polymerase alpha activity and inefficient repair process during G2 phase is involved in the expression of FRA3B.

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Year:  1986        PMID： 3793108     DOI： 10.1007/bf00280503

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

Review 1.  Reduction of ribonucleotides.

Authors:  L Thelander; P Reichard
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

Review 2.  DNA repair and its coupling to DNA replication in eukaryotic cells.

Authors:  J E Cleaver
Journal:  Biochim Biophys Acta       Date:  1978-12-11

3.  Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites.

Authors:  R Berger; C D Bloomfield; G R Sutherland
Journal:  Cytogenet Cell Genet       Date:  1985

4.  A new familial "fragile site" on chromosome 16 (q23-24). Cytogenetic and clinical considerations.

Authors:  F Shabtai; D Klar; R Nissimov; D Vardimon; J Hart; I Halbrecht
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

5.  Human chromosome hot points. 1. Hot point at 3p14 in three populations.

Authors:  X T Zhou; B H Xu; C L Chu; G F Xia; N Li; R Sha
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

6.  DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

Authors:  T W Glover; C Berger; J Coyle; B Echo
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

7.  Constitutive fragile sites and cancer.

Authors:  J J Yunis; A L Soreng
Journal:  Science       Date:  1984-12-07       Impact factor: 47.728

8.  The effect of cytosine arabinoside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatment.

Authors:  E A Hiss; R J Preston
Journal:  Biochim Biophys Acta       Date:  1977-09-06

9.  Synergistic enhancement of the frequency of chromatid aberrations in cultured human lymphocytes by combinations of inhibitors of DNA repair.

Authors:  B A Kihlman; H C Andersson
Journal:  Mutat Res       Date:  1985 Jun-Jul       Impact factor: 2.433

10.  Human chromosome hot points. IV. Uridine-induced hot-point breaks at 3p14 and 16q23-24 and increased expression of fragile site Xq27 in folate-free medium.

Authors:  N Li; X T Zhou
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132
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  6 in total

1.  Induction of distamycin A-inducible rare fragile sites and increased sister chromatid exchanges at the fragile site.

Authors:  H Tsuji; A Hitomi; E Takahashi; M Murata; T Ikeuchi; K Yamamoto; S Tsuji; T Hori
Journal:  Hum Genet       Date:  1991-07       Impact factor: 4.132

2.  Fragile sites and statistics.

Authors:  T Mariani
Journal:  Hum Genet       Date:  1989-03       Impact factor: 4.132

3.  Synergistic effect of hydroxyurea and excessive thymidine on the expression of the common fragile sites at 3p14 and 16q23.

Authors:  Z A Yan; X Z Li; X T Zhou
Journal:  Hum Genet       Date:  1988-12       Impact factor: 4.132

4.  Aphidicolin, DNA repair, and fragile sites.

Authors:  J A Reidy
Journal:  Hum Genet       Date:  1988-02       Impact factor: 4.132

5.  The effect of hydroxyurea on the expression of the common fragile site at 3p14.

Authors:  Z A Yan; X Z Li; X T Zhou
Journal:  J Med Genet       Date:  1987-10       Impact factor: 6.318

Review 6.  Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?

Authors:  Alexandros G Georgakilas; Petros Tsantoulis; Athanassios Kotsinas; Ioannis Michalopoulos; Paul Townsend; Vassilis G Gorgoulis
Journal:  Cell Mol Life Sci       Date:  2014-09-20       Impact factor: 9.261
  6 in total

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