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Literature DB >> 6239375

Constitutive fragile sites and cancer.

Abstract

Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.

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Year: 1984 PMID： 6239375 DOI： 10.1126/science.6239375

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

159 in total

1. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability.

Authors: A Hellman; A Rahat; S W Scherer; A Darvasi; L C Tsui; B Kerem
Journal: Mol Cell Biol Date: 2000-06 Impact factor: 4.272

2. Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.

Authors: F Toledo; A Coquelle; E Svetlova; M Debatisse
Journal: Nucleic Acids Res Date: 2000-12-01 Impact factor: 16.971

3. Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks.

Authors: Lewis R Roberts; Nicholas F LaRusso
Journal: World J Gastroenterol Date: 2000-02 Impact factor: 5.742

Constitutive fragile sites and cancer.

1. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability.

2. Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.

3. Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks.

4. Molecular basis for expression of common and rare fragile sites.

5. Increased expression of 5q31 fragile site in a Bloom syndrome family.

6. Increased genetic instability of the common fragile site at 3p14 after integration of exogenous DNA.

7. A palindrome-mediated mechanism distinguishes translocations involving LCR-B of chromosome 22q11.2.

8. Non random distribution of lesions induced by deoxyribonuclease I in human chromosomes.

9. Telomere association of chromosomes induced by aphidicolin in a normal individual.

10. Genetic determination of fragile-site expression.