Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Transcriptional and posttranscriptional regulation of exogenous human beta interferon gene in simian cells defective in interferon synthesis.

Literature DB >> 3785197

Transcriptional and posttranscriptional regulation of exogenous human beta interferon gene in simian cells defective in interferon synthesis.

Abstract

We determined that the defect in beta interferon induction in Vero cells is due to the absence of the simian beta interferon (IFN-beta) gene. Nevertheless, the human IFN-beta gene or a hybrid gene, in which the human IFN-beta promoter-regulatory region directs expression of the chloramphenicol acetyltransferase gene (pIFN-CAT), could be induced in transfected Vero cells, and these cells also regulated IFN-beta mRNA (but not pIFN-CAT mRNA) posttranscriptionally. These results indicate that the instability in the human IFN-beta gene is coded for by the coding or 3'-end region of IFN-beta mRNA and that the human IFN-beta gene is regulated in Vero and human cells in an identical manner.

Entities: Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3785197 PMCID： PMC367773 DOI： 10.1128/mcb.6.6.2279-2283.1986

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

32 in total

1. Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production.

Authors: J M Emeny; M J Morgan
Journal: J Gen Virol Date: 1979-04 Impact factor: 3.891

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

3. Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates.

Authors: R F Weaver; C Weissmann
Journal: Nucleic Acids Res Date: 1979-11-10 Impact factor: 16.971

4. Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.

Authors: N B Raj; P M Pitha
Journal: Proc Natl Acad Sci U S A Date: 1981-12 Impact factor: 11.205

5. Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells.

Authors: S Ohno; T Taniguchi
Journal: Nucleic Acids Res Date: 1982-02-11 Impact factor: 16.971

6. Effect of interferon on the exogenous Friend murine leukemia virus infection.

Authors: C H Riggin; P M Pitha
Journal: Virology Date: 1982-04-15 Impact factor: 3.616

7. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

8. Appearance of interferon inducibility and sensitivity during differentiation of murine teratocarcinoma cells in vitro.

Authors: D C Burke; C F Graham; J M Lehman
Journal: Cell Date: 1978-02 Impact factor: 41.582

9. Differential activation of hybrid genes containing herpes simplex virus immediate-early or delayed-early promoters after superinfection of stable DNA-transfected cell lines.

Authors: J D Mosca; G R Reyes; P M Pitha; G S Hayward
Journal: J Virol Date: 1985-12 Impact factor: 5.103

10. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors: J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal: Biochemistry Date: 1979-11-27 Impact factor: 3.162

121 in total

1. Virus replication in engineered human cells that do not respond to interferons.

Authors: D F Young; L Andrejeva; A Livingstone; S Goodbourn; R A Lamb; P L Collins; R M Elliott; R E Randall
Journal: J Virol Date: 2003-02 Impact factor: 5.103

2. Transient expression of the beta interferon promoter in human cells.

Authors: S Xanthoudakis; D Alper; J Hiscott
Journal: Mol Cell Biol Date: 1987-10 Impact factor: 4.272

3. Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodies.

Authors: T S Carlos; R Fearns; R E Randall
Journal: J Virol Date: 2005-11 Impact factor: 5.103

4. Rift valley fever virus nonstructural protein NSs promotes viral RNA replication and transcription in a minigenome system.

Authors: Tetsuro Ikegami; C J Peters; Shinji Makino
Journal: J Virol Date: 2005-05 Impact factor: 5.103

5. Identification of human parainfluenza virus type 2 (HPIV-2) V protein amino acid residues that reduce binding of V to MDA5 and attenuate HPIV-2 replication in nonhuman primates.

Authors: Anne Schaap-Nutt; Caraline Higgins; Emerito Amaro-Carambot; Sheila M Nolan; Christopher D'Angelo; Brian R Murphy; Peter L Collins; Alexander C Schmidt
Journal: J Virol Date: 2011-02-02 Impact factor: 5.103

6. Posttranscriptional regulation of beta interferon expression in erythroid Friend cells treated with gamma interferon.

Authors: G Marziali; G Fiorucci; E M Coccia; Z Percario; J Raber; A Battistini; G B Rossi; E Affabris; G Romeo
Journal: J Virol Date: 1991-08 Impact factor: 5.103

7. Cell fusion-induced activation of interferon-stimulated genes is not required for restriction of a herpes simplex virus VP16/ICP0 mutant in heterokarya formed between permissive and restrictive cells.

Authors: Meaghan H Hancock; Karen L Mossman; James R Smiley
Journal: J Virol Date: 2009-06-17 Impact factor: 5.103