Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production.

Literature DB >> 113494

Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production.

Abstract

A clone of Vero cells was isolated and shown to be totally unable to synthesize interferon and insensitive to the toxic effect of poly(rI).poly(rC) treatment. Cells of this clone and mouse L cells were fused by treatment with polyethylene glycol or Sendai virus. Hybrid cell clones were isolated following selection in medium containing hypoxanthine, thymidine and ouabain. The hybrids were sensitive to the antiviral effect of poly(rI).poly(rC) and synthesized mouse, but not primate, interferon. It is proposed that in Vero cells, the gene for interferon synthesis is defective or absent.

Entities: Chemical Disease Species

Mesh：

Substances：
Interferons
Poly I-C

Year: 1979 PMID： 113494 DOI： 10.1099/0022-1317-43-1-247

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

Keyword Cloud
Cited

192 in total

1. West Nile virus infection induces depletion of IFNAR1 protein levels.

Authors: Jared D Evans; Rachel A Crown; Ji A Sohn; Christoph Seeger
Journal: Viral Immunol Date: 2011-08 Impact factor: 2.257

2. Involvement of the rabies virus phosphoprotein gene in neuroinvasiveness.

Authors: Satoko Yamaoka; Naoto Ito; Seii Ohka; Shohei Kaneda; Hiroko Nakamura; Takahiro Agari; Tatsunori Masatani; Keisuke Nakagawa; Kazuma Okada; Kota Okadera; Hiromichi Mitake; Teruo Fujii; Makoto Sugiyama
Journal: J Virol Date: 2013-09-11 Impact factor: 5.103

3. The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses.

Authors: Peter J Alff; Irina N Gavrilovskaya; Elena Gorbunova; Karen Endriss; Yuson Chong; Erika Geimonen; Nandini Sen; Nancy C Reich; Erich R Mackow
Journal: J Virol Date: 2006-10 Impact factor: 5.103

4. Modelling dynamics of the type I interferon response to in vitro viral infection.

Authors: Tom J Howat; Cristina Barreca; Peter O'Hare; Julia R Gog; Bryan T Grenfell
Journal: J R Soc Interface Date: 2006-10-22 Impact factor: 4.118

5. Identification of human parainfluenza virus type 2 (HPIV-2) V protein amino acid residues that reduce binding of V to MDA5 and attenuate HPIV-2 replication in nonhuman primates.

Authors: Anne Schaap-Nutt; Caraline Higgins; Emerito Amaro-Carambot; Sheila M Nolan; Christopher D'Angelo; Brian R Murphy; Peter L Collins; Alexander C Schmidt
Journal: J Virol Date: 2011-02-02 Impact factor: 5.103

6. Novel influenza virus NS1 antagonists block replication and restore innate immune function.

Authors: Dipanwita Basu; Marcin P Walkiewicz; Matthew Frieman; Ralph S Baric; David T Auble; Daniel A Engel
Journal: J Virol Date: 2008-12-03 Impact factor: 5.103

7. Naturally occurring substitutions in the P/V gene convert the noncytopathic paramyxovirus simian virus 5 into a virus that induces alpha/beta interferon synthesis and cell death.

Authors: Elizabeth K Wansley; Griffith D Parks
Journal: J Virol Date: 2002-10 Impact factor: 5.103