Literature DB >> 3759083

Human chromosome hot points. V. The effect of four nucleosides on chromosomes in folate-free medium.

N Li, Y Wu, X T Zhou.   

Abstract

Human lymphocytes from 18 healthy adults were cultured in minimal essential medium without folic acid. The addition of 4 mM cytidine or 1 mM guanosine to cultures 24 h prior to harvest produced a statistically significant increase in hot point 3p14 breaks. An excess of 3 mM adenosine or thymidine had no such effect on the hot point. The mechanism of the effects of nucleosides on hot points was discussed.

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Year:  1986        PMID： 3759083     DOI： 10.1007/bf00278795

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  14 in total

1.  Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects.

Authors:  S Aymé; J F Mattei; M G Mattei; Y Aurran; F Giraud
Journal:  Hum Genet       Date:  1976-02-29       Impact factor: 4.132

2.  Distribution of spontaneous chromosome breaks in human chromosomes.

Authors:  P Aula; H von Koskull
Journal:  Hum Genet       Date:  1976-05-19       Impact factor: 4.132

3.  Characterization of a mutator gene in Chinese hamster ovary cells.

Authors:  M Meuth; N L'Heureux-Huard; M Trudel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

4.  Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites.

Authors:  G Barbi; P Steinbach; W Vogel
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

5.  The genotoxic potential of bases and nucleosides.

Authors:  D Anderson; C R Richardson; P J Davies
Journal:  Mutat Res       Date:  1981-05       Impact factor: 2.433

6.  Excess thymidine induces folate sensitive fragile sites.

Authors:  G R Sutherland; E Baker; A Fratini
Journal:  Am J Med Genet       Date:  1985-10

7.  DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

Authors:  T W Glover; C Berger; J Coyle; B Echo
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

8.  Methotrexate-induced misincorporation of uracil into DNA.

Authors:  M Goulian; B Bleile; B Y Tseng
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

9.  Effects of nucleotides on expression of the folate sensitive fragile sites.

Authors:  G R Sutherland; E Baker
Journal:  Am J Med Genet       Date:  1986 Jan-Feb

10.  Human chromosome hot points. IV. Uridine-induced hot-point breaks at 3p14 and 16q23-24 and increased expression of fragile site Xq27 in folate-free medium.

Authors:  N Li; X T Zhou
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132
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  2 in total

1.  Fragile sites and statistics.

Authors:  T Mariani
Journal:  Hum Genet       Date:  1989-03       Impact factor: 4.132

2.  The effect of hydroxyurea on the expression of the common fragile site at 3p14.

Authors:  Z A Yan; X Z Li; X T Zhou
Journal:  J Med Genet       Date:  1987-10       Impact factor: 6.318
  2 in total

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