Literature DB >> 375236

Aflatoxin B1 mutagenesis, DNA binding, and adduct formation in Salmonella typhimurium.

A A Stark, J M Essigmann, A L Demain, T R Skopek, G N Wogan.   

Abstract

Salmonella typhimurium strain TM677 was mutagenized with aflatoxin B1 (AFB1) in liquid suspension culture in the presence of a rat liver postmitochondrial supernatant. Forward mutation to 8-azaguanine resistance was measured in the treated cultures and was found to increase linearly with AFB1 concentration. DNA purified from mutagenized cells was analyzed for AFB1 adduct formation by high-pressure liquid chromatography after adduct liberation. AFB1 exposures at 0.16 and 0.32 micrometer for 35 min produced 15 and 22 AFB1--DNA adducts per genome, respectively, and induced 8-azaguanine-resistant fractions of 4.9 X 10(-4) and 9.6 X 10(-4). Approximately 70% of the AFB1 bound to DNA was chromatographically identical to 2,3-dihydro-2-(N7-guanyl)-3-hydroxyaflatoxin B1 at the two AFB1 levels used.

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Year:  1979        PMID： 375236      PMCID： PMC383247          DOI： 10.1073/pnas.76.3.1343

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Determination of nucleic acids in animal tissues.

Authors:  G CERIOTTI
Journal:  J Biol Chem       Date:  1955-05       Impact factor: 5.157

2.  Acetylornithinase of Escherichia coli: partial purification and some properties.

Authors:  H J VOGEL; D M BONNER
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

3.  Nucleic acid synthesis and the division cycle of Salmonella typhimurium.

Authors:  K G LARK; O MAALOE
Journal:  Biochim Biophys Acta       Date:  1956-09

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants.

Authors:  M D Alper; B N Ames
Journal:  J Bacteriol       Date:  1978-01       Impact factor: 3.490

6.  2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo.

Authors:  J K Lin; J A Miller; E C Miller
Journal:  Cancer Res       Date:  1977-12       Impact factor: 12.701

7.  Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

Authors:  J M Essigmann; R G Croy; A M Nadzan; W F Busby; V N Reinhold; G Büchi; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

8.  Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.

Authors:  T R Skopek; H L Liber; D A Kaden; W G Thilly
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

9.  Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker.

Authors:  T R Skopek; H L Liber; J J Krolewski; W G Thilly
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

10.  Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.

Authors:  D H Swenson; J K Lin; E C Miller; J A Miller
Journal:  Cancer Res       Date:  1977-01       Impact factor: 12.701
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  7 in total

1.  Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine.

Authors:  Leslie A Bransfield; Alissa Rennie; Kala Visvanathan; Shelly-Ann Odwin; Thomas W Kensler; James D Yager; Marlin D Friesen; John D Groopman
Journal:  Chem Res Toxicol       Date:  2008-06-27       Impact factor: 3.739

2.  Effect of varying the exposure and 3H-thymidine labeling period upon the outcome of the primary hepatocyte DNA repair assay.

Authors:  T R Barfknecht; D J Mecca; R W Naismith
Journal:  Cell Biol Toxicol       Date:  1988-06       Impact factor: 6.691

3.  Depurination causes mutations in SOS-induced cells.

Authors:  R M Schaaper; L A Loeb
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

4.  Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene sequences of rat liver DNA.

Authors:  T R Irvin; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

5.  Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay.

Authors:  A Haugen; J D Groopman; I C Hsu; G R Goodrich; G N Wogan; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

6.  Aminofluorene-DNA adduct formation in Salmonella typhimurium exposed to the carcinogen N-hydroxy-2-acetylaminofluorene.

Authors:  D T Beranek; G L White; R H Heflich; F A Beland
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

7.  Toxicity mechanisms of aflatoxin M1 assisted with molecular docking and the toxicity-limiting role of trans-resveratrol.

Authors:  İlknur Güç; Emine Yalçin; Kültiğin Çavuşoğlu; Ali Acar
Journal:  Sci Rep       Date:  2022-08-25       Impact factor: 4.996
  7 in total

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