Literature DB >> 187331

Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.

D H Swenson, J K Lin, E C Miller, J A Miller.   

Abstract

Administration of[3H]aflatoxin B2 (2,3-dihydroaflatoxin B1)(AFB2) to male rats resulted in levels of hepatic DNA- and ribosomal(r)RNA-aflatoxin adducts that were about 1% of those for rats given [3H]aflatoxin B1(AFB1). The levels of hepatic protein-aflatoxin adducts were 35 to 70% as great for AFB2-treated as compared to AFB1-treated rats...

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Year:  1977        PMID： 187331

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  29 in total

Review 1.  Metabolism of a prototype mycotoxin, aflatoxin B1, and its genetic regulation.

Authors:  H L Gurtoo; R Dahms; J B Vaught
Journal:  Mycopathologia       Date:  1978-12-18       Impact factor: 2.574

2.  Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.

Authors:  Kyle L Brown; James Z Deng; Rajkumar S Iyer; Lalitha G Iyer; Markus W Voehler; Michael P Stone; Constance M Harris; Thomas M Harris
Journal:  J Am Chem Soc       Date:  2006-11-29       Impact factor: 15.419

3.  Genetic variation of physiological response to aflatoxin in Gallus domesticus.

Authors:  G M Lanza; K W Washburn; R D Wyatt; H L Marks
Journal:  Theor Appl Genet       Date:  1982-09       Impact factor: 5.699

4.  Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine.

Authors:  A D D'Andrea; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

5.  Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

Authors:  J M Essigmann; R G Croy; A M Nadzan; W F Busby; V N Reinhold; G Büchi; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

6.  Covalent binding of aflatoxin B1 to liver DNA in rats pretreated with ethanol.

Authors:  M Marinovich; W K Lutz
Journal:  Experientia       Date:  1985-10-15

7.  Different tissue responses of mixed function oxidases and detoxifying enzymes to aflatoxin B1 administration in the rat.

Authors:  N Singh; J Clausen
Journal:  Br J Exp Pathol       Date:  1980-12

8.  Mutational properties of the primary aflatoxin B1-DNA adduct.

Authors:  E A Bailey; R S Iyer; M P Stone; T M Harris; J M Essigmann
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

9.  Aflatoxin B1 mutagenesis, DNA binding, and adduct formation in Salmonella typhimurium.

Authors:  A A Stark; J M Essigmann; A L Demain; T R Skopek; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

10.  Restricted repair of aflatoxin B1 induced damage in alpha DNA of monkey cells.

Authors:  S A Leadon; M E Zolan; P C Hanawalt
Journal:  Nucleic Acids Res       Date:  1983-08-25       Impact factor: 16.971
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