Literature DB >> 3707545

Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate.

H R Fatania, T C Vary, P J Randle.   

Abstract

The activity of pyruvate dehydrogenase kinase in extracts of mitochondria from rat hepatocytes cultured for 21 h in medium 199 was increased 2.5-fold by the presence of 55 nM-glucagon and 1 mM-sodium n-octanoate in the culture medium. The change was comparable with that induced in vivo by 48 h starvation. The potential contribution of branched-chain complex to estimates of PDH-complex activity in rat liver mitochondria has been defined.

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Year:  1986        PMID： 3707545      PMCID： PMC1146552          DOI： 10.1042/bj2340233

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  Calcium metabolism in rat hepatocytes.

Authors:  S Foden; P J Randle
Journal:  Biochem J       Date:  1978-03-15       Impact factor: 3.857

2.  Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat.

Authors:  N J Hutson; A L Kerbey; P J Randle; P H Sugden
Journal:  Biochem J       Date:  1978-08-01       Impact factor: 3.857

3.  The mode of regulation of pyruvate dehydrogenase of lactating rat mammary gland. Effects of starvation and insulin.

Authors:  M A Baxter; H G Coore
Journal:  Biochem J       Date:  1978-08-15       Impact factor: 3.857

4.  Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.

Authors:  T C Linn; F H Pettit; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1969-01       Impact factor: 11.205

5.  Relationshiop between phosphorylation and activity of pyruvate dehydrogenase in rat liver mitochondria and the absence of such a relationship for pyruvate carboxylase.

Authors:  A B Leiter; M Weinberg; F Isohashi; M F Utter
Journal:  J Biol Chem       Date:  1978-04-25       Impact factor: 5.157

6.  Effects of branched chain alpha-ketoacids on the metabolism of isolated rat liver cells. III. Interactions with pyruvate dehydrogenase.

Authors:  E Walajtys-Rode; J R Williamson
Journal:  J Biol Chem       Date:  1980-01-25       Impact factor: 5.157

7.  Enhanced activity of pyruvate dehydrogenase kinase in rat heart mitochondria in alloxan-diabetes or starvation.

Authors:  N J Hutson; P J Randle
Journal:  FEBS Lett       Date:  1978-08-01       Impact factor: 4.124

8.  Branched chain 2-oxo-acid dehydrogenase complex of rat liver.

Authors:  P J Parker; P J Randle
Journal:  FEBS Lett       Date:  1978-06-01       Impact factor: 4.124

9.  Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria.

Authors:  J G McCormack
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

10.  Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

Authors:  A L Kerbey; P M Radcliffe; P J Randle
Journal:  Biochem J       Date:  1977-06-15       Impact factor: 3.857
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  20 in total

1.  Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle.

Authors:  Paul J LeBlanc; Sandra J Peters; Rebecca J Tunstall; David Cameron-Smith; George J F Heigenhauser
Journal:  J Physiol       Date:  2004-03-12       Impact factor: 5.182

Review 2.  Fuel selection and carbon flux during the starved-to-fed transition.

Authors:  M C Sugden; M J Holness; T N Palmer
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

3.  Evidence that rat liver pyruvate dehydrogenase kinase activator protein is a pyruvate dehydrogenase kinase.

Authors:  S C Mistry; D A Priestman; A L Kerbey; P J Randle
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

4.  An improved assay for pyruvate dehydrogenase in liver and heart.

Authors:  P J Randle
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

5.  Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation.

Authors:  M J Holness; M C Sugden
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

6.  Pyruvate dehydrogenase-complex activity in brown adipose tissue of gold thioglucose-obese mice.

Authors:  G J Cooney; G S Denyer; A L Kerbey; R L Frankland; S C Blair; P F Williams; I D Caterson
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857

7.  The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state.

Authors:  T J French; A W Goode; M J Holness; P A MacLennan; M C Sugden
Journal:  Biochem J       Date:  1988-12-15       Impact factor: 3.857

8.  Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes.

Authors:  D R Marchington; A L Kerbey; A E Jones; P J Randle
Journal:  Biochem J       Date:  1987-08-15       Impact factor: 3.857

9.  Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria.

Authors:  G S Denyer; A L Kerbey; P J Randle
Journal:  Biochem J       Date:  1986-10-15       Impact factor: 3.857

10.  Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes.

Authors:  C G Jones; S K Hothi; M A Titheradge
Journal:  Biochem J       Date:  1993-02-01       Impact factor: 3.857
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