Literature DB >> 2039454

Evidence that rat liver pyruvate dehydrogenase kinase activator protein is a pyruvate dehydrogenase kinase.

S C Mistry1, D A Priestman, A L Kerbey, P J Randle.   

Abstract

It is shown here that rat liver pyruvate dehydrogenase (PDH) kinase activator protein (KAP) catalyses ATP-dependent inactivation and [32P]phosphorylation of pig heart PDHE1 and of yeast (Saccharomyces cerevisiae) PDH complex devoid of PDH kinase activity, that fluorosulphonylbenzoyladenosine inactivates rat liver KAP and the intrinsic PDH kinase of rat liver PDH complex, and that KAP, like PDH kinase, is inactivated by thiol-reactive reagents. It is concluded that KAP is a free PDH kinase.

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Year:  1991        PMID： 2039454      PMCID： PMC1150121          DOI： 10.1042/bj2750775

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Pyruvate dehydrogenase kinase from bovine kidney.

Authors:  F H Pettit; S J Yeaman; L J Reed
Journal:  Methods Enzymol       Date:  1982       Impact factor: 1.600

2.  Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes.

Authors:  D R Marchington; A L Kerbey; M G Giardina; A E Jones; P J Randle
Journal:  Biochem J       Date:  1989-01-15       Impact factor: 3.857

3.  Phosphorylation-dephosphorylation of pyruvate dehydrogenase from bakers' yeast.

Authors:  D J Uhlinger; C Y Yang; L J Reed
Journal:  Biochemistry       Date:  1986-09-23       Impact factor: 3.162

4.  Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney.

Authors:  W M Teague; F H Pettit; T L Wu; S R Silberman; L J Reed
Journal:  Biochemistry       Date:  1982-10-26       Impact factor: 3.162

5.  Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria.

Authors:  G S Denyer; A L Kerbey; P J Randle
Journal:  Biochem J       Date:  1986-10-15       Impact factor: 3.857

6.  The roles of intrinsic kinase and of kinase/activator protein in the enhanced phosphorylation of pyruvate dehydrogenase complex in starvation.

Authors:  A L Kerbey; L J Richardson; P J Randle
Journal:  FEBS Lett       Date:  1984-10-15       Impact factor: 4.124

7.  Effects of low-protein diet and starvation on the activity of branched-chain 2-oxo acid dehydrogenase kinase in rat liver and heart.

Authors:  J Espinal; M Beggs; H Patel; P J Randle
Journal:  Biochem J       Date:  1986-07-01       Impact factor: 3.857

8.  Pyruvate dehydrogenase kinase activity of pig heart pyruvate dehydrogenase (E1 component of pyruvate dehydrogenase complex).

Authors:  A L Kerbey; P J Randle
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

9.  Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate.

Authors:  H R Fatania; T C Vary; P J Randle
Journal:  Biochem J       Date:  1986-02-15       Impact factor: 3.857

10.  Studies on the oxidative metabolism of Saccharomyces cerevisiae. II. Morphology and oxidative phosphorylation capacity of mitochondria and derived particles from baker's yeast.

Authors:  E VITOLS; A W LINNANE
Journal:  J Biophys Biochem Cytol       Date:  1961-03
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  7 in total

1.  Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle.

Authors:  Paul J LeBlanc; Sandra J Peters; Rebecca J Tunstall; David Cameron-Smith; George J F Heigenhauser
Journal:  J Physiol       Date:  2004-03-12       Impact factor: 5.182

2.  Metabolic responses of pyruvate decarboxylase-negative Saccharomyces cerevisiae to glucose excess.

Authors:  M T Flikweert; J P van Dijken; J T Pronk
Journal:  Appl Environ Microbiol       Date:  1997-09       Impact factor: 4.792

3.  Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase.

Authors:  D A Priestman; S C Mistry; A Halsall; P J Randle
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857

4.  Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle.

Authors:  T C Vary; S Hazen
Journal:  Mol Cell Biochem       Date:  1999-08       Impact factor: 3.396

5.  Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase.

Authors:  O J Park; D Cesar; D Faix; K Wu; C H Shackleton; M K Hellerstein
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

6.  Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase.

Authors:  M C Sugden; L G Fryer; K A Orfali; D A Priestman; E Donald; M J Holness
Journal:  Biochem J       Date:  1998-01-01       Impact factor: 3.857

Review 7.  Mechanisms modifying glucose oxidation in diabetes mellitus.

Authors:  P J Randle; D A Priestman; S Mistry; A Halsall
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122
  7 in total

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