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Literature DB >> 3314865

Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes.

D R Marchington¹, A L Kerbey, A E Jones, P J Randle.

Abstract

In tissue culture of hepatocytes, insulin (0.1-1 munits/ml for 4 h) reversed completely the effects of starvation of rats to decrease the activity of pyruvate dehydrogenase (PDH) complex and to increase the activities of PDH kinase and PDH kinase activator protein. It had no effect in hepatocytes from fed rats. Significant effects of insulin were detected with 0.01 munit/ml after 4 h, and in 1-2 h with 1 munit/ml.

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Year: 1987 PMID： 3314865 PMCID： PMC1148263 DOI： 10.1042/bj2460233

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

20 in total

1. Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue.

Authors: W A Hughes; R M Denton
Journal: Nature Date: 1976-12-02 Impact factor: 49.962

2. Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.

Authors: T C Linn; F H Pettit; L J Reed
Journal: Proc Natl Acad Sci U S A Date: 1969-01 Impact factor: 11.205

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Authors: R M Denton; H G Coore; B R Martin; P J Randle
Journal: Nat New Biol Date: 1971-05-26

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Authors: O H Wieland
Journal: Rev Physiol Biochem Pharmacol Date: 1983 Impact factor: 5.545

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Authors: C Jarrousse; B Lardeux; G Bourdel; A Girard-Globa; G Rosselin
Journal: J Nutr Date: 1980-09 Impact factor: 4.798

6. Parallel increases in rates of fatty acid synthesis and in pyruvate dehydrogenase activity in isolated rat hepatocytes incubated with insulin.

Authors: F Assimacopoulos-Jeannet; J G McCormack; M Prentki; B Jeanrenaud; R M Denton
Journal: Biochim Biophys Acta Date: 1982-07-16

7. Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.

Authors: I D Caterson; S J Fuller; P J Randle
Journal: Biochem J Date: 1982-10-15 Impact factor: 3.857

8. Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria.

Authors: G S Denyer; A L Kerbey; P J Randle
Journal: Biochem J Date: 1986-10-15 Impact factor: 3.857

9. Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation.

Authors: A L Kerbey; P J Randle
Journal: Biochem J Date: 1982-07-15 Impact factor: 3.857

10. Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon.

Authors: F Assimacopoulos-Jeannet; J G McCormack; B Jeanrenaud
Journal: FEBS Lett Date: 1983-08-08 Impact factor: 4.124

11 in total

Review 1. Fuel selection and carbon flux during the starved-to-fed transition.

Authors: M C Sugden; M J Holness; T N Palmer
Journal: Biochem J Date: 1989-10-15 Impact factor: 3.857

2. Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation.

Authors: M J Holness; M C Sugden
Journal: Biochem J Date: 1989-03-01 Impact factor: 3.857

3. The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition.

Authors: M J Holness; P A MacLennan; T N Palmer; M C Sugden
Journal: Biochem J Date: 1988-06-01 Impact factor: 3.857

4. Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase.

Authors: M C Sugden; L G Fryer; K A Orfali; D A Priestman; E Donald; M J Holness
Journal: Biochem J Date: 1998-01-01 Impact factor: 3.857

5. Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes.

Authors: D R Marchington; A L Kerbey; M G Giardina; A E Jones; P J Randle
Journal: Biochem J Date: 1989-01-15 Impact factor: 3.857

6. Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat cardiac myocytes.

Authors: D R Marchington; A L Kerbey; P J Randle
Journal: Biochem J Date: 1990-04-01 Impact factor: 3.857

7. Pyruvate dehydrogenase activities and rates of lipogenesis during the fed-to-starved transition in liver and brown adipose tissue of the rat.

Authors: M J Holness; M C Sugden
Journal: Biochem J Date: 1990-05-15 Impact factor: 3.857

8. The regulation of hepatic carbon flux by pyruvate dehydrogenase and pyruvate dehydrogenase kinase during long-term food restriction.

Authors: M C Sugden; R M Grimshaw; M J Holness
Journal: Biochem J Date: 1993-11-15 Impact factor: 3.857

9. Insulin-independent and extremely rapid switch in the partitioning of hepatic fatty acids from oxidation to esterification in starved-refed diabetic rats. Possible roles for changes in cell pH and volume.

Authors: A M Moir; V A Zammit
Journal: Biochem J Date: 1995-02-01 Impact factor: 3.857

10. Hepatic carbon flux after re-feeding in the glycogen-storage-disease (gsd/gsd) rat.

Authors: M J Holness; T N Palmer; E B Worrall; M C Sugden
Journal: Biochem J Date: 1987-12-15 Impact factor: 3.857