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Literature DB >> 3689338

The derivation and interpretation of control coefficients.

Abstract

1. Equations for control coefficients are derived by using a method that generates all the control coefficients for a system in a single procedure. This requires solving fewer simultaneous equations than an equivalent method based on 'control theorems'. 2. The interpretation of control coefficients is discussed: in particular, it is shown that these functions are unsatisfactory as measures of 'control' and are perhaps best used as a means of testing control theories (models).

Mesh：

Year: 1987 PMID： 3689338 PMCID： PMC1148377 DOI： 10.1042/bj2470113

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

15 in total

Review 1. Advanced modeling and identification techniques for metabolic processes.

Authors: G Belforte; B Bona; M Milanese
Journal: Crit Rev Biomed Eng Date: 1984

Review 2. Modern theories of metabolic control and their applications (review).

Authors: H V Westerhoff; A K Groen; R J Wanders
Journal: Biosci Rep Date: 1984-01 Impact factor: 3.840

3. Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation.

Authors: D C LaPorte; D E Koshland
Journal: Nature Date: 1983 Sep 22-28 Impact factor: 49.962

4. Metabolic control and its analysis. Additional relationships between elasticities and control coefficients.

Authors: D A Fell; H M Sauro
Journal: Eur J Biochem Date: 1985-05-02

5. The control of enzyme systems in vivo: elasticity analysis of the steady state.

Authors: H Kacser
Journal: Biochem Soc Trans Date: 1983-01 Impact factor: 5.407

6. Quantification of the contribution of various steps to the control of mitochondrial respiration.

Authors: A K Groen; R J Wanders; H V Westerhoff; R van der Meer; J M Tager
Journal: J Biol Chem Date: 1982-03-25 Impact factor: 5.157

7. Rate-limiting steps in metabolic pathways.

Authors: R Rognstad
Journal: J Biol Chem Date: 1979-03-25 Impact factor: 5.157

8. The control of flux.

Authors: H Kacser; J A Burns
Journal: Symp Soc Exp Biol Date: 1973

9. Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon.

Authors: A K Groen; C W van Roermund; R C Vervoorn; J M Tager
Journal: Biochem J Date: 1986-07-15 Impact factor: 3.857

8. Rapid enzyme assays investigating the variation in the glycolytic pathway in field-caught populations of Fundulus heteroclitus.

Authors: V A Pierce; D L Crawford
Journal: Biochem Genet Date: 1994-10 Impact factor: 1.890

9. Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria.

Authors: R P Hafner; G C Brown; M D Brand
Journal: Biochem J Date: 1990-02-01 Impact factor: 3.857

10. Pyrimidine homeostasis is accomplished by directed overflow metabolism.

Authors: Marshall Louis Reaves; Brian D Young; Aaron M Hosios; Yi-Fan Xu; Joshua D Rabinowitz
Journal: Nature Date: 2013-07-31 Impact factor: 49.962

The derivation and interpretation of control coefficients.

Review 1. Advanced modeling and identification techniques for metabolic processes.

Review 2. Modern theories of metabolic control and their applications (review).

3. Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation.

4. Metabolic control and its analysis. Additional relationships between elasticities and control coefficients.

5. The control of enzyme systems in vivo: elasticity analysis of the steady state.

6. Quantification of the contribution of various steps to the control of mitochondrial respiration.

7. Rate-limiting steps in metabolic pathways.

8. The control of flux.

9. Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon.

10. The frequency of different types of heart disease in South African Blacks at a cardiac referral center.

1. Unraveling the complex regulatory relationships between metabolism and signal transduction in cancer.

Review 2. Metabolic control analysis: a survey of its theoretical and experimental development.

3. Quantitative analysis of metabolic regulation. A graph-theoretic approach using spanning trees.

Review 4. The micro-architecture of the cerebral cortex: functional neuroimaging models and metabolism.

5. Calculation of control coefficients of metabolic pathways. A flux-oriented graph-theoretic approach.

6. A simplified method for calculating complex metabolic sensitivities by using matrix partitioning.

7. Control analysis provides a simple means of understanding the control structure of a metabolic pathway.

8. Rapid enzyme assays investigating the variation in the glycolytic pathway in field-caught populations of Fundulus heteroclitus.

9. Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria.

10. Pyrimidine homeostasis is accomplished by directed overflow metabolism.