Literature DB >> 2604700

A simplified method for calculating complex metabolic sensitivities by using matrix partitioning.

B Crabtree1, G Collins, M I Franklin.   

Abstract

The matrix method for calculating the overall sensitivities (including control coefficients) of a metabolic system, described by Crabtree & Newsholme [Biochem. J. 247, 113-129 (1987)], is simplified by a preliminary partitioning of the initial matrix equation. This reduces the size of the matrix to be inverted and thereby removes a major drawback with the original method. The resulting procedure is simpler and more systematic than the alternative methods currently available, especially when the system is extensively branched.

Mesh：

Year:  1989        PMID： 2604700      PMCID： PMC1133422          DOI： 10.1042/bj2630289

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Accuracy of alternative representations for integrated biochemical systems.

Authors:  E O Voit; M A Savageau
Journal:  Biochemistry       Date:  1987-10-20       Impact factor: 3.162

2.  Control analysis of biochemical pathways: a novel procedure for calculating control coefficients, and an additional theorem for branched pathways.

Authors:  C Giersch
Journal:  J Theor Biol       Date:  1988-10-21       Impact factor: 2.691

Review 3.  MOlecular democracy: who shares the controls?

Authors:  H Kacser; J A Burns
Journal:  Biochem Soc Trans       Date:  1979-10       Impact factor: 5.407

4.  The derivation and interpretation of control coefficients.

Authors:  B Crabtree; E A Newsholme
Journal:  Biochem J       Date:  1987-10-01       Impact factor: 3.857

5.  Control analysis of metabolic networks. 2. Total differentials and general formulation of the connectivity relations.

Authors:  C Giersch
Journal:  Eur J Biochem       Date:  1988-06-15

Review 6.  Metabolic regulation and mathematical models.

Authors:  R Heinrich; S M Rapoport; T A Rapoport
Journal:  Prog Biophys Mol Biol       Date:  1977       Impact factor: 3.667

7.  Metabolic control and its analysis. Extensions to the theory and matrix method.

Authors:  H M Sauro; J R Small; D A Fell
Journal:  Eur J Biochem       Date:  1987-05-15

Review 8.  A quantitative approach to metabolic control.

Authors:  B Crabtree; E A Newsholme
Journal:  Curr Top Cell Regul       Date:  1985

9.  Metabolic control and its analysis. Additional relationships between elasticities and control coefficients.

Authors:  D A Fell; H M Sauro
Journal:  Eur J Biochem       Date:  1985-05-02

10.  The control of flux.

Authors:  H Kacser; J A Burns
Journal:  Symp Soc Exp Biol       Date:  1973
View more
  2 in total

Review 1.  Metabolic control analysis: a survey of its theoretical and experimental development.

Authors:  D A Fell
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

2.  Calculation of control coefficients of metabolic pathways. A flux-oriented graph-theoretic approach.

Authors:  A K Sen
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.