Literature DB >> 6312317

Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation.

D C LaPorte, D E Koshland.   

Abstract

The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, has been found to occur in the reversible phosphorylation of isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed.

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Year:  1983        PMID： 6312317     DOI： 10.1038/305286a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  64 in total

1.  Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated.

Authors:  O G Berg; J Paulsson; M Ehrenberg
Journal:  Biophys J       Date:  2000-09       Impact factor: 4.033

2.  Isocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity.

Authors:  T P Ikeda; E Houtz; D C LaPorte
Journal:  J Bacteriol       Date:  1992-02       Impact factor: 3.490

3.  A kinetic re-interpretation of the regulation of rabbit skeletal-muscle phosphorylase kinase activity by Ca2+ and phosphorylation.

Authors:  P Newsholme; D A Walsh
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

4.  Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.

Authors:  Jimin Zheng; Zongchao Jia
Journal:  Nature       Date:  2010-05-26       Impact factor: 49.962

5.  Multiple kinetic states for the flagellar motor switch.

Authors:  S C Kuo; D E Koshland
Journal:  J Bacteriol       Date:  1989-11       Impact factor: 3.490

6.  Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.

Authors:  J H Hurley; P E Thorsness; V Ramalingam; N H Helmers; D E Koshland; R M Stroud
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

7.  Glyoxylate bypass operon of Escherichia coli: cloning and determination of the functional map.

Authors:  T Chung; D J Klumpp; D C LaPorte
Journal:  J Bacteriol       Date:  1988-01       Impact factor: 3.490

8.  Ca2+ regulation of 1-(3-sn-phosphatidyl)-1D-myo-inositol 4-phosphate formation and hydrolysis on sarcoplasmic-reticular Ca2+-transport ATPase. A new principle of phospholipid turnover regulation.

Authors:  M Schäfer; G Behle; M Varsányi; L M Heilmeyer
Journal:  Biochem J       Date:  1987-11-01       Impact factor: 3.857

9.  Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli.

Authors:  Sumana Venkat; Hao Chen; Alleigh Stahman; Denver Hudson; Paige McGuire; Qinglei Gan; Chenguang Fan
Journal:  J Mol Biol       Date:  2018-05-04       Impact factor: 5.469

Review 10.  The acetate switch.

Authors:  Alan J Wolfe
Journal:  Microbiol Mol Biol Rev       Date:  2005-03       Impact factor: 11.056
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