Literature DB >> 3687946

Direct detection of usual and atypical alleles on the human aldehyde dehydrogenase-2 (ALDH2) locus.

L C Hsu1, R E Bendel, A Yoshida.   

Abstract

A method for determining human mitochondrial aldehyde dehydrogenase (ALDH2) genotypes was developed. Two 21-base synthetic oligonucleotides, one complementary to the usual ALDH2(1) gene and the other complementary to the atypical ALDH2(2) gene, were used as specific probes for in-gel hybridization analysis of human genomic DNA from either peripheral blood cells or livers. Under appropriate hybridization conditions, these two probes can hybridize to their specific complementary alleles and thus allow the genotyping of the ALDH2 locus.

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Year:  1987        PMID： 3687946      PMCID： PMC1684351     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  16 in total

1.  A general method for isolation of high molecular weight DNA from eukaryotes.

Authors:  N Blin; D W Stafford
Journal:  Nucleic Acids Res       Date:  1976-09       Impact factor: 16.971

2.  Oligonucleotide hybridization techniques.

Authors:  C G Miyada; R B Wallace
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

3.  Racial differences in alcohol sensitivity: a new hypothesis.

Authors:  H W Goedde; S Harada; D P Agarwal
Journal:  Hum Genet       Date:  1979-10-02       Impact factor: 4.132

4.  Isolation and characterization of aldehyde dehydrogenase isozymes from usual and atypical human livers.

Authors:  M Ikawa; C C Impraim; G Wang; A Yoshida
Journal:  J Biol Chem       Date:  1983-05-25       Impact factor: 5.157

5.  Prenatal diagnosis of beta-thalassemia. Detection of a single nucleotide mutation in DNA.

Authors:  M Pirastu; Y W Kan; A Cao; B J Conner; R L Teplitz; R B Wallace
Journal:  N Engl J Med       Date:  1983-08-04       Impact factor: 91.245

6.  Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity.

Authors:  C Impraim; G Wang; A Yoshida
Journal:  Am J Hum Genet       Date:  1982-11       Impact factor: 11.025

7.  Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides.

Authors:  B J Conner; A A Reyes; C Morin; K Itakura; R L Teplitz; R B Wallace
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

8.  A foreign beta-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues.

Authors:  E Lacy; S Roberts; E P Evans; M D Burtenshaw; F D Costantini
Journal:  Cell       Date:  1983-09       Impact factor: 41.582

9.  Alcohol metabolizing enzymes: studies of isozymes in human biopsies and cultured fibroblasts.

Authors:  H W Goedde; D P Agarwal; S Harada
Journal:  Clin Genet       Date:  1979-07       Impact factor: 4.438

10.  Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: gene deletion and its possible implications in alcohol metabolism.

Authors:  Y S Teng
Journal:  Biochem Genet       Date:  1981-02       Impact factor: 1.890
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  20 in total

Review 1.  Gene frequencies of alcohol dehydrogenase2 and aldehyde dehydrogenase2 in Northwest Coast Amerindians.

Authors:  S H Chen; M Zhang; C R Scott
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

2.  Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption.

Authors:  D W Crabb
Journal:  J Clin Invest       Date:  1990-02       Impact factor: 14.808

3.  Effects of genetic polymorphisms in alcohol-metabolizing enzymes on alcohol hypersensitivity and alcohol-related health problems in orientals.

Authors:  T Takeshita; K Morimoto
Journal:  Environ Health Prev Med       Date:  1996-04       Impact factor: 3.674

4.  Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

Authors:  D W Crabb; H J Edenberg; W F Bosron; T K Li
Journal:  J Clin Invest       Date:  1989-01       Impact factor: 14.808

5.  Detection of Borrelia burgdorferi using the polymerase chain reaction.

Authors:  D C Malloy; R K Nauman; H Paxton
Journal:  J Clin Microbiol       Date:  1990-06       Impact factor: 5.948

6.  Genotype of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers.

Authors:  A Shibuya; M Yasunami; A Yoshida
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

7.  Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele.

Authors:  S Singh; G Fritze; B L Fang; S Harada; Y K Paik; R Eckey; D P Agarwal; H W Goedde
Journal:  Hum Genet       Date:  1989-09       Impact factor: 4.132

8.  Genotyping of mitochondrial aldehyde dehydrogenase in blood samples using allele-specific oligonucleotides: comparison with phenotyping in hair roots.

Authors:  H W Goedde; S Singh; D P Agarwal; G Fritze; K Stapel; Y K Paik
Journal:  Hum Genet       Date:  1989-03       Impact factor: 4.132

9.  Frequency of the atypical aldehyde dehydrogenase-2 gene (ALDH2(2)) in Japanese and Caucasians.

Authors:  A Shibuya; A Yoshida
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

10.  Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease.

Authors:  A Shibuya; A Yoshida
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025
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