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Literature DB >> 2703232

Genotyping of mitochondrial aldehyde dehydrogenase in blood samples using allele-specific oligonucleotides: comparison with phenotyping in hair roots.

H W Goedde¹, S Singh, D P Agarwal, G Fritze, K Stapel, Y K Paik.

Abstract

Deficiency of mitochondrial aldehyde dehydrogenase (ALDH I) is an inborn error of metabolism that is responsible for acute alcohol sensitivity (flushing response) observed only in Orientals of Mongoloid origin. Our previous studies using electrophoretic enzyme detection have shown that this deficiency is prevalent among Japanese, Chinese, and other Orientals. We report here the genotyping of ALDH I locus in blood samples of 218 South Korean individuals by means of hybridization analysis with allele-specific oligonucleotide probes and enzymatically amplified human genomic DNA. The results of genotyping are compared with the phenotype analysis in hair roots of the same individuals. Among 62 apparently deficient phenotypes, 58 heterozygote and 4 homozygote deficient genotypes were observed.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1989 PMID： 2703232 DOI： 10.1007/BF00283679

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

19 in total

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Authors: H W Goedde; D P Agarwal; R Eckey; S Harada
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17 in total

Review 1. Medicobiological and genetic studies on alcoholism. Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality.

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Journal: Clin Investig Date: 1992-06

Review 2. Genetic predisposition to alcoholic liver disease.

Authors: C P Day; M F Bassendine
Journal: Gut Date: 1992-11 Impact factor: 23.059

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Journal: Hum Genet Date: 1992-01 Impact factor: 4.132

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Authors: Q Xiao; H Weiner; T Johnston; D W Crabb
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Authors: T Takeshita; K Morimoto
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Authors: S Fukuda; K Morimoto
Journal: Environ Health Prev Med Date: 2001-04 Impact factor: 3.674

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Journal: J Clin Invest Date: 1996-11-01 Impact factor: 14.808

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Journal: Hum Genet Date: 1989-09 Impact factor: 4.132

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Journal: Int Arch Occup Environ Health Date: 1993 Impact factor: 3.015